Peptide and Oligonucleotide CDMO Market

Peptide and Oligonucleotide CDMO Market Sizes by Type (Peptides and Oligonucleotides), By Application (Pharmaceutical and Biotechnology Companies, Research Institutes and Others), Regions, Global Industry Analysis, Share, Growth, Trends, and Forecast 2024 to 2033

Base Year: 2023 Historical Data: 2020-22
  • Report ID: TBI-14184
  • Published Date: Mar, 2024
  • Pages: 238
  • Category: Healthcare
  • Format: PDF
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The global peptide and oligonucleotide CDMO market was valued at USD 2.49 billion in 2023 and is anticipated to grow at a CAGR of 11.5% from 2024 to 2033. CDMOs have become pivotal players in the production of medications and are widely trusted as flexible third-party service providers. They support pharmaceutical companies throughout all stages of generating drugs, from research and development services for new medicines to manufacturing these products while providing formulation and finishing processes. CDMOs have adjusted their business model through internal investments alongside strategic merger & acquisition initiatives to meet changing client demands. Previously restricted mainly to external provision of mature drug-manufacturing services, CDMOs now lead innovation by encompassing broader areas such as pharma-service provisioning across various medical fields - not limited to assembly lines alone but boosting revenue streams via this newfound approach towards a diverse altered business outlook.

Market Introduction:

Short chains of amino acids, known as peptides, serve as the basic units for proteins. They are essential in various biological functions and perform vital tasks such as acting as signal carriers, enzymes or structural elements. Due to their high accuracy in targeting specific molecules and limited side effects when used appropriately, pharmaceutical companies have increasingly utilized peptide therapeutics. The production process requires highly specialized comprehension of matters related to chemistry formulation specifically tailored towards peptide manufacturing methods with precision knowledge required. Compared to long DNA and RNA strands, oligonucleotides are short sequences of nucleotides that serve as their basic building blocks. Oligonucleotide-derived medications have become a promising group of treatments for genetic and uncommon diseases by regulating gene expression. The development process involves intricate methods such as purification techniques and solid-phase synthesis to design these compounds effectively.

In contrast, oligonucleotides are brief groupings of nucleotides which comprise the fundamental components of RNA and DNA. Oligonucleotide-derived medicines have surfaced as promising remedies that change gene expression to treat genetic disorders or uncommon diseases. Due to their complicated creation method and advanced solid-phase synthesis techniques employed during production, designing high-quality oligonucleotides requires sophisticated purification methods. Essentially, CDMOs handle the entire drug development and production process on behalf of their clients through outsourcing.

Peptide and Oligonucleotide CDMO Market Size

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Recent Development
  • In May 2023: GenScript Biotech Corporation expanded its primary manufacturing plant in Zhenjiang, Jiangsu, China, emphasizing the production of oligonucleotides and peptides. qPCR, NGS, RNA, and DNA oligos are just a few products that can now be produced due to improved oligonucleotide synthesis capabilities. This extension will facilitate various applications, including genome editing, RNA interference, and molecular diagnostics.
  • In October 2022: EUROAPI announced a USD 19.7 million initial investment to install state-of-the-art manufacturing equipment at its Frankfurt site. This project would allow EUROAPI to meet the increasing demand for peptides and oligonucleotides in the Contract Development and Manufacturing Organization (CDMO) sector.

Market Dynamics:

Drivers

Rising Incidences of Chronic Diseases - Peptide and oligonucleotide therapeutics are in high demand due to the rising incidences of chronic diseases such as obesity, cancer and other cardiovascular disorders worldwide. These treatment options provide precise therapy tailored to individuals' unique circumstances. This aspect makes peptide and oligonucleotide treatment desirable for managing complicated long-term conditions. As chronic diseases increase globally, pharmaceutical companies look towards partnering with CDMOs to develop innovative drugs based on peptides and oligonucleotides. The growing trend of personalized medicine has driven the demand for peptide and oligonucleotide therapeutics. These molecules exhibit exceptional accuracy in targeting specific areas within a person's body, thus aligning with the objectives of customized medicines - offering efficient treatment options that avoid complications. The increasing demand for personalized medicine directly impacts the peptide and oligonucleotide CDMO market by triggering further development of tailored drug solutions.

Restraints:

Stringent Regulatory Scenario – Peptides and oligonucleotides operate in an intricate and continuously evolving regulatory environment. Meeting compliance requirements can be challenging, especially for groundbreaking molecules with unique traits. CDMOs are responsible for navigating complicated legal frameworks, staying up-to-date with changing directives, and accounting for specific demands tied to peptide and oligonucleotide development/manufacturing—all while adding an extra layer of complexity throughout the entire process. The global peptide and oligonucleotide CDMO market encounters challenges due to drug development's inherent dangers, including unanticipated toxic effects, inadequate effectiveness or unforeseen clinical results. Investment in peptides and oligonucleotides' progress by business organizations confronts uncertainties during trial phases; failure could negatively influence demand for CDMO services or cause the desertion of specific ventures.  

Opportunities:

Adoption of Outsourcing Strategies - The global peptide and oligonucleotide CDMO market is experiencing huge growth due to the ongoing trend of outsourcing drug development and manufacturing activities. Pharmaceutical companies realize the benefits of entrusting non-core tasks to specialized service providers, such as cost management, access to distinctive expertise, and improved peptide/oligonucleotide complexity navigation. Peptide and oligonucleotide CDMO services have seen an increase in demand due to the progress made in drug delivery technologies. Advancements such as nanoparticle-based systems, sustained-release formulas, and targeted approaches have triggered adaptations by manufacturing processes, which are vital for CDMOs. As this global population continues to rise, demand for medications like peptides and oligonucleotides is anticipated to rise, leading towards further expansion within the market.

Regional segmentation analysis:

The regions analyzed for the market include North America, Europe, South America, Asia Pacific, the Middle East, and Africa. North America region emerged as the most prominent global peptide and oligonucleotide CDMO market, with a 39.0% market revenue share in 2023. North America is a dominant region within the global peptide and oligonucleotide CDMO market, attributed predominantly to significant contributions from Canada and the United States. The region's dynamic pharmaceutical industry, well-established healthcare infrastructure, and favourable regulatory environment create ideal conditions that position North America as one of the best in class for this marketplace. Technological advancements and a predominant focus on research and development in the United States propel the demand for specialized CDMO services. This region's dedication to precision medicine and personalized therapies coincides with the competencies of peptide and oligonucleotide CDMOs, rendering it an essential market for growth and development. The regional market players also use various market strategies such as product innovation, product differentiation, mergers, acquisitions, partnerships, and strategic alliances to maintain their competitive edge.

North America Region Peptide and Oligonucleotide CDMO Market Share in 2023 - 39.0%

 

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  • In June 2022: Agilent Technologies and Merck agreed to develop Process Analytical Technologies (PAT). With this collaboration, Merck and Agilent Technologies are addressing a need in the downstream PAT market. Using the advanced analytical technologies of Agilent Technologies and Merck's bioprocess portfolio, the latter enhances downstream processing with real-time monitoring and automated process control of key process parameters (CPPs) and critical quality attributes (CQAs).
Type Segment Analysis

The type segment includes oligonucleotides and peptides. The peptides segment dominated, with a market share of around 58% in 2023. Several factors influence the increase in demand for CDMO services catering to peptides. The enhancement of peptide synthesis technologies and understanding of peptide biology have resulted in a surge in popularity for peptides, owing to their precision targeting capabilities with minimal side effects. Consequently, pharmaceutical firms are seeking specialized CDMOs that can assist them with developing drug treatment options based on these potent molecules. In addition, the growing utilization of peptides in treating ailments like diabetes, cardiovascular diseases, and cancer is boosting their market dominance. Peptides' ability to emulate natural signaling molecules and regulate biological pathways makes them effective treatment options. This is the primary factor for the segment's growth.

Application Segment Analysis

The application segment is bifurcated into pharmaceutical and biotechnology companies, research institutes and others. The pharmaceutical and biotechnology companies segment dominated, with a market share of around 54% in 2023. Due to their ongoing pursuit of innovation and the need for faster drug development activities, pharmaceutical and biotechnology companies hold a significant portion of the Peptide and Oligonucleotide CDMO market. Because peptide and oligonucleotide manufacturing require vast resources with complex procedures, these businesses frequently rely on specialized CDMOs' infrastructure and expertise. The growing interest in precision medicine, personalized therapies and the inclusion of peptides and oligonucleotides into drug development pipelines is driving an increase in market share for pharmaceutical and biotechnology companies. CDMOs play a major role by offering customized solutions to these firms, significantly contributing to their market growth; outsourcing specialized manufacturing activities allows them to concentrate on their primary strengths.

Some of the Key Market Players:
  • Bachem
  • PolyPeptide Group
  • Sylentis, S.A.
  • STA Pharmaceutical Co. Ltd.
  • Creative Peptides
  • Curia Global, Inc.
  • EUROAPI
  • Merck KGaA
  • Aurigene Pharmaceutical Services Ltd.
  • CordenPharm

Report Description:

Attribute Description
Market Size Revenue (USD Billion)
Market size value in 2023 USD 2.49 Billion
Market size value in 2033 USD 7.40 Billion
CAGR (2024 to 2033) 11.5%
Historical data 2020-2022
Base Year 2023
Forecast 2024-2033
Region The regions analyzed for the market are Asia Pacific, Europe, South America, North America, and Middle East & Africa. Furthermore, the regions are further analyzed at the country level.
Segments Application, Type

Frequesntly Asked Questions

As per The Brainy Insights, the size of the peptide and oligonucleotide CDMO market was valued at 2.49 billion in 2023 to USD 7.40 billion by 2033.

The global peptide and oligonucleotide CDMO market is growing at a CAGR of 11.5% during the forecast period 2024-2033.

North America region became the largest market for peptide and oligonucleotide CDMO.

The rising incidences of chronic diseases is driving the market's growth.

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This study forecasts revenue at global, regional, and country levels from 2020 to 2033. The Brainy Insights has segmented the global peptide and oligonucleotide CDMO market based on below-mentioned segments:

Global Peptide and Oligonucleotide CDMO Market by Type:

  • Peptides
  • Oligonucleotides

Global Peptide and Oligonucleotide CDMO Market by Application:

  • Pharmaceutical and Biotechnology Companies
  • Research Institutes
  • Others

Global Peptide and Oligonucleotide CDMO Market by Region:

  • North America
    • U.S.
    • Canada
    • Mexico
  • Europe
    • Germany
    • France
    • U.K.
    • Italy
    • Spain
  • Asia-Pacific
    • Japan
    • China
    • India
  • South America
    • Brazil
  • Middle East and Africa  
    • UAE
    • South Africa

Methodology

Research has its special purpose to undertake marketing efficiently. In this competitive scenario, businesses need information across all industry verticals; the information about customer wants, market demand, competition, industry trends, distribution channels etc. This information needs to be updated regularly because businesses operate in a dynamic environment. Our organization, The Brainy Insights incorporates scientific and systematic research procedures in order to get proper market insights and industry analysis for overall business success. The analysis consists of studying the market from a miniscule level wherein we implement statistical tools which helps us in examining the data with accuracy and precision. 

Our research reports feature both; quantitative and qualitative aspects for any market. Qualitative information for any market research process are fundamental because they reveal the customer needs and wants, usage and consumption for any product/service related to a specific industry. This in turn aids the marketers/investors in knowing certain perceptions of the customers. Qualitative research can enlighten about the different product concepts and designs along with unique service offering that in turn, helps define marketing problems and generate opportunities. On the other hand, quantitative research engages with the data collection process through interviews, e-mail interactions, surveys and pilot studies. Quantitative aspects for the market research are useful to validate the hypotheses generated during qualitative research method, explore empirical patterns in the data with the help of statistical tools, and finally make the market estimations.

The Brainy Insights offers comprehensive research and analysis, based on a wide assortment of factual insights gained through interviews with CXOs and global experts and secondary data from reliable sources. Our analysts and industry specialist assume vital roles in building up statistical tools and analysis models, which are used to analyse the data and arrive at accurate insights with exceedingly informative research discoveries. The data provided by our organization have proven precious to a diverse range of companies, facilitating them to address issues such as determining which products/services are the most appealing, whether or not customers use the product in the manner anticipated, the purchasing intentions of the market and many others.

Our research methodology encompasses an idyllic combination of primary and secondary initiatives. Key phases involved in this process are listed below:

MARKET RESEARCH PROCESS

Data Procurement:

The phase involves the gathering and collecting of market data and its related information with the help of different sources & research procedures.

The data procurement stage involves in data gathering and collecting through various data sources.

This stage involves in extensive research. These data sources includes:

Purchased Database: Purchased databases play a crucial role in estimating the market sizes irrespective of the domain. Our purchased database includes:

  • The organizational databases such as D&B Hoovers, and Bloomberg that helps us to identify the competitive scenario of the key market players/organizations along with the financial information.
  • Industry/Market databases such as Statista, and Factiva provides market/industry insights and deduce certain formulations. 
  • We also have contractual agreements with various reputed data providers and third party vendors who provide information which are not limited to:
    • Import & Export Data
    • Business Trade Information
    • Usage rates of a particular product/service on certain demographics mainly focusing on the unmet prerequisites

Primary Research: The Brainy Insights interacts with leading companies and experts of the concerned domain to develop the analyst team’s market understanding and expertise. It improves and substantiates every single data presented in the market reports. Primary research mainly involves in telephonic interviews, E-mail interactions and face-to-face interviews with the raw material providers, manufacturers/producers, distributors, & independent consultants. The interviews that we conduct provides valuable data on market size and industry growth trends prevailing in the market. Our organization also conducts surveys with the various industry experts in order to gain overall insights of the industry/market. For instance, in healthcare industry we conduct surveys with the pharmacists, doctors, surgeons and nurses in order to gain insights and key information of a medical product/device/equipment which the customers are going to usage. Surveys are conducted in the form of questionnaire designed by our own analyst team. Surveys plays an important role in primary research because surveys helps us to identify the key target audiences of the market. Additionally, surveys helps to identify the key target audience engaged with the market. Our survey team conducts the survey by targeting the key audience, thus gaining insights from them. Based on the perspectives of the customers, this information is utilized to formulate market strategies. Moreover, market surveys helps us to understand the current competitive situation of the industry. To be precise, our survey process typically involve with the 360 analysis of the market. This analytical process begins by identifying the prospective customers for a product or service related to the market/industry to obtain data on how a product/service could fit into customers’ lives.

Secondary Research: The secondary data sources includes information published by the on-profit organizations such as World bank, WHO, company fillings, investor presentations, annual reports, national government documents, statistical databases, blogs, articles, white papers and others. From the annual report, we analyse a company’s revenue to understand the key segment and market share of that organization in a particular region. We analyse the company websites and adopt the product mapping technique which is important for deriving the segment revenue. In the product mapping method, we select and categorize the products offered by the companies catering to domain specific market, deduce the product revenue for each of the companies so as to get overall estimation of the market size. We also source data and analyses trends based on information received from supply side and demand side intermediaries in the value chain. The supply side denotes the data gathered from supplier, distributor, wholesaler and the demand side illustrates the data gathered from the end customers for respective market domain.

The supply side for a domain specific market is analysed by:

  • Estimating and projecting penetration rates through analysing product attributes, availability of internal and external substitutes, followed by pricing analysis of the product.
  • Experiential assessment of year-on-year sales of the product by conducting interviews.

The demand side for the market is estimated through:

  • Evaluating the penetration level and usage rates of the product.
  • Referring to the historical data to determine the growth rate and evaluate the industry trends

In-house Library: Apart from these third-party sources, we have our in-house library of qualitative and quantitative information. Our in-house database includes market data for various industry and domains. These data are updated on regular basis as per the changing market scenario. Our library includes, historic databases, internal audit reports and archives.

Sometimes there are instances where there is no metadata or raw data available for any domain specific market. For those cases, we use our expertise to forecast and estimate the market size in order to generate comprehensive data sets. Our analyst team adopt a robust research technique in order to produce the estimates:

  • Applying demographic along with psychographic segmentation for market evaluation
  • Determining the Micro and Macro-economic indicators for each region 
  • Examining the industry indicators prevailing in the market. 

Data Synthesis: This stage involves the analysis & mapping of all the information obtained from the previous step. It also involves in scrutinizing the data for any discrepancy observed while data gathering related to the market. The data is collected with consideration to the heterogeneity of sources. Robust scientific techniques are in place for synthesizing disparate data sets and provide the essential contextual information that can orient market strategies. The Brainy Insights has extensive experience in data synthesis where the data passes through various stages:

  • Data Screening: Data screening is the process of scrutinising data/information collected from primary research for errors and amending those collected data before data integration method. The screening involves in examining raw data, identifying errors and dealing with missing data. The purpose of the data screening is to ensure data is correctly entered or not. The Brainy Insights employs objective and systematic data screening grades involving repeated cycles of quality checks, screening and suspect analysis.
  • Data Integration: Integrating multiple data streams is necessary to produce research studies that provide in-depth picture to the clients. These data streams come from multiple research studies and our in house database. After screening of the data, our analysts conduct creative integration of data sets, optimizing connections between integrated surveys and syndicated data sources. There are mainly 2 research approaches that we follow in order to integrate our data; top down approach and bottom up approach.

Market Deduction & Formulation: The final stage comprises of assigning data points at appropriate market spaces so as to deduce feasible conclusions. Analyst perspective & subject matter expert based holistic form of market sizing coupled with industry analysis also plays a crucial role in this stage.

This stage involves in finalization of the market size and numbers that we have collected from data integration step. With data interpolation, it is made sure that there is no gap in the market data. Successful trend analysis is done by our analysts using extrapolation techniques, which provide the best possible forecasts for the market.

Data Validation & Market Feedback: Validation is the most important step in the process. Validation & re-validation via an intricately designed process helps us finalize data-points to be used for final calculations.

The Brainy Insights interacts with leading companies and experts of the concerned domain to develop the analyst team’s market understanding and expertise. It improves and substantiates every single data presented in the market reports. The data validation interview and discussion panels are typically composed of the most experienced industry members. The participants include, however, are not limited to:

  • CXOs and VPs of leading companies’ specific to sector
  • Purchasing managers, technical personnel, end-users
  • Key opinion leaders such as investment bankers, and industry consultants

Moreover, we always validate our data and findings through primary respondents from all the major regions we are working on.

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