Recombinant Proteins Market

Recombinant Proteins Market Size by Product Type (Growth Factor, Antibodies, Antigens, Enzymes, Hormones and Others), Application (Drug Discovery and Development, Research Application, Therapeutic Use, Diagnostics, and Others), End User (Biotechnology and Pharmaceutical Companies, Academic Research Institutes, Contract Research Organizations and Others), Regions, Global Industry Analysis, Share, Growth, Trends, and Forecast 2024 to 2033

Base Year: 2023 Historical Data: 2020-22
  • Report ID: TBI-14114
  • Published Date: Feb, 2024
  • Pages: 237
  • Category: Food & Beverages
  • Format: PDF
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The global recombinant proteins market was valued at USD 3 billion in 2023 and grew at a CAGR of 8% from 2024 to 2033. The market is expected to reach USD 6.47 billion by 2033. The growing applications of recombinant proteins in medicine will drive the growth of the global recombinant proteins market.

Market Introduction:

Recombinant proteins are synthesized through genetic engineering. They are formed by combining genetic material from different sources by inserting a gene encoding a specific protein into the DNA of a host organism. The organism can be bacteria, yeast, or mammalian cells. They serve as therapeutics for various diseases, including insulin for diabetes and growth hormone for growth disorders, as well as in producing vaccines. They are essential tools in research laboratories for studying protein structure, function, and drug discovery. They are used to produce enzymes for food processing, detergents, and biopharmaceuticals. They are scalable and offer pure, consistent, cost-effective drug development, making them suitable for large-scale production. Recombinant proteins offer various applications in medicine, research, and industry.

Recombinant Proteins Market Size

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Recent Development
  • Global biotechnology company Dyadic International, Inc. stated that it has entered into a fully financed evaluation agreement with a top, unnamed biopharmaceutical company worldwide to design and produce recombinant proteins using Dyadic's microbial protein production platform based on C1 filamentous fungal. As per the agreement, the collaborator will bear the research and development financial burden. Dyadic is dedicated to supporting its associates and partners in developing efficacious therapeutic and prophylactic interventions worldwide.

Market Dynamics:

Drivers

The growing applications of recombinant proteins in modern medicine – Recombinant proteins are useful and highly effective in addressing global health challenges, including infectious diseases, pandemics, and bioterrorism threats. These proteins aid in the creation of safe, effective, and scalable vaccines for a range of diseases threatening the modern world. Recombinant proteins facilitate the accurate detection of pathogens in clinical samples, enabling early detection, surveillance, and monitoring of infectious diseases. Additionally, recombinant proteins offer targeted and precise treatments for infectious diseases. Recombinant proteins are valuable in preventing, diagnosing, and treating infectious diseases and other health threats worldwide, contributing significantly to global health efforts, which makes them important and in demand globally. Therefore, the growing applications of recombinant proteins in modern medicine to tackle global health challenges will contribute to the global market's growth and development.

Restraints:

The high costs and complex nature of recombinant proteins The production process involves gene cloning, protein expression, and purification. All of these stages require specialized knowledge, equipment, and resources. Additionally, scaling up production from successful laboratory experiments to industrial scale increases complexity and resource requirements, adding to costs. Purifying recombinant proteins from biological mixtures is costly and time-consuming. Additionally, meeting regulatory standards for safety, efficacy, and quality adds to the complexity and cost of development and commercialization. Therefore, the cost and complexity associated with each recombinant protein production and application stage will hamper the market's growth.

Opportunities:

Technological advancements, research and innovation – Advancements in biotechnology, research, and innovation have significantly expanded the scope of applications of recombinant proteins in the future. These proteins have the potential to revolutionize precision medicine and facilitate customized treatments for several lifestyle diseases plaguing the world. They also have potential applications in immunotherapy for combating diseases such as cancer and gene editing, and therapy offers potential treatments for genetic disorders and other diseases. Technological advancements and research will enable stakeholders to unravel the potential of these proteins. Therefore, technological advancements, research and innovation will contribute to the global recombinant market's growth during the forecast period.

Regional segmentation analysis:

The regions analyzed for the market include North America, Europe, South America, Asia Pacific, the Middle East, and Africa. North America emerged as the most significant global recombinant proteins market, with a 44% market revenue share in 2023.

The substantial investment and funding from government agencies, private investors, and venture capital firms foster a conducive environment for research and development, thereby contributing to the regional market's growth. Well-established regulatory agencies with clear and streamlined regulatory pathways for product approval ensure that safety and efficacy standards are met, which furthers the market's growth. The advanced infrastructure, state-of-the-art research facilities, and access to cutting-edge technologies and resources facilitate collaboration, contributing to the market’s growth and development.

North America Region Recombinant Proteins Market Share in 2023 - 44%

 

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  • US-made headgear Leading life sciences company Cytiva unveiled Cytiva Protein Select, a cutting-edge technology that speeds up and simplifies the purification of recombinant proteins. Using different affinity binding partners for each protein during purification with the self-cleaving traceless tag and complementary affinity chromatography resin is no longer essential, standardising purification for all proteins.
Product type Segment Analysis

The product type segment is divided into growth factors, antibodies, antigens, enzymes, hormones and others. The growth factor segment dominated the market, with a market share of around 37% in 2023. The growth factor is a class of recombinant proteins vital in regulating cellular processes. Growth factors are essential in promoting wound healing, bone regeneration, and tissue repair. Additionally, they are implicated in cancer biology and present promising avenues for cancer treatment. Growth factors are critical in cell culture, tissue engineering, and stem cell research. Recombinant growth factors find applications in the production of therapeutic proteins, vaccines, and biopharmaceuticals, as well as in developing novel cell-based therapies and regenerative medicine approaches. Therefore, the diverse applications of growth factors contribute to its growing dominance in the market.

  • The newest generation of secondary antibodies, called Multi-rAb Recombinant Secondary Antibodies, has been introduced by Proteintech, a leading manufacturer of recombinant proteins, immunoassay kits, and antibodies worldwide. These antibodies are intended to provide unparalleled specificity and repeatability in commonly used immunoassays.
Application Segment Analysis

The application segment is divided into drug discovery and development, research application, therapeutic use, diagnostics, and others. The drug discovery and development segment dominated the market, with a market share of around 38% in 2023. Recombinant proteins enable researchers to identify and validate potential drug targets. Recombinant proteins play a critical role in rational drug design and optimization efforts guiding the development of drug candidates. Recombinant proteins offer scalable and cost-effective means of producing therapeutics. They also contribute to the advancement of personalized medicine approaches. Therefore, the vital role of recombinant proteins in drug discovery and development translates to its wide adoption and application in the field.  

  • Nucleus Biologics, The Cell Performance Company, a leading supplier of customized cell culture media solutions for the cell and gene therapy industry, signed a manufacturing, distribution, and cooperation agreement with Core Biogenesis, a pioneer in the field of recombinant human proteins expressed in plants, to jointly provide more defined and affordable reagents and media to the cell and gene therapy market. By this arrangement, Nucleus Biologics becomes a distributor for the cell and gene therapy market and the GMP manufacturer of recombinant proteins produced by Core Biogenesis. Furthermore, Nucleus Biologics and Stoic Bio, their sister firm, will make these recombinant proteins available for use in their KrakatoaTM pod-based media manufacturing systems. 
End-user Segment Analysis

The end-user segment is divided into biotechnology and pharmaceutical companies, academic research institutes, contract research organizations and others. The biotechnology and pharmaceutical companies segment dominated the market, with a market share of around 40% in 2023. Biotechnology and pharmaceutical companies extensively utilize recombinant proteins throughout various drug discovery, development, and production stages. Recombinant proteins are instrumental in the realm of biopharmaceutical development. These companies produce these proteins at large scales, enabling their use in clinical applications. Additionally, recombinant proteins find applications in diagnostic assays, advancing drug discovery, development, and healthcare innovation in the biotechnology and pharmaceutical industries.

  • Jenthera Therapeutics, a gene editing startup focused on delivering CRISPR ribonucleoproteins (RNPs), and Future Fields, a trailblazing biotechnology company that developed the first synthetic biology system in history to use fruit flies for recombinant protein production, announced a partnership centred on the production of a novel cancer-fighting protein. This innovative protein under research will be mass-produced more economically and sustainably using the Future Fields platform, the EntoEngine, than traditional biopharmaceutical production methods. Future Fields is aggressively forming research partnerships with large and small biotech companies for strategically important proteins. With its adaptable platform, the company is well-positioned to sustainably lead the way in efficiently and economically mass-producing complex, targeted proteins.
Some of the Key Market Players:
  • Abnova Corp.
  • Bio-Rad Laboratories, Inc.
  • Enzo Life Sciences, Inc.
  • GenScript
  • Merck KGaA
  • Proteintech Group, Inc.
  • R&D Systems, Inc.
  • RayBiotech Life Inc.
  • Sino Biological, Inc.
  • Thermo Fisher Scientific

Report Description:

Attribute Description
Market Size Revenue (USD Billion)
Market size value in 2023 USD 3 Billion
Market size value in 2033 USD 6.47 Billion
CAGR (2024 to 2033) 8%
Historical data 2020-2022
Base Year 2023
Forecast 2024-2033
Region The regions analyzed for the market are Asia Pacific, Europe, South America, North America, and Middle East and Africa. Furthermore, the regions are further analyzed at the country level.
Segments Product Type, Application and End User

Frequesntly Asked Questions

As per The Brainy Insights, the size of the global recombinant proteins market was valued at USD 3 billion in 2023 to USD 6.47 billion by 2033.

Global recombinant proteins market is growing at a CAGR of 8% during the forecast period 2024-2033.

The market's growth will be influenced by the growing applications of recombinant proteins in modern medicine.

The high costs and complex nature of recombinant proteins could hamper the market growth.

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This study forecasts revenue at global, regional, and country levels from 2020 to 2033. The Brainy Insights has segmented the global recombinant proteins market based on below mentioned segments:

Global Recombinant Proteins Market by Product Type:

  • Growth Factor
  • Antibodies
  • Antigens
  • Enzymes
  • Hormones
  • Others

Global Recombinant Proteins Market by Application:

  • Drug Discovery and Development
  • Research Application
  • Therapeutic Use
  • Diagnostics
  • Others

Global Recombinant Proteins Market by End User:

  • Biotechnology and Pharmaceutical Companies
  • Academic Research Institutes
  • Contract Research Organizations
  • Others

Global Recombinant Proteins Market by Region:

  • North America
    • U.S.
    • Canada
    • Mexico
  • Europe
    • Germany
    • France
    • U.K.
    • Italy
    • Spain
  • Asia-Pacific
    • Japan
    • China
    • India
  • South America
    • Brazil
  • Middle East and Africa  
    • UAE
    • South Africa

Methodology

Research has its special purpose to undertake marketing efficiently. In this competitive scenario, businesses need information across all industry verticals; the information about customer wants, market demand, competition, industry trends, distribution channels etc. This information needs to be updated regularly because businesses operate in a dynamic environment. Our organization, The Brainy Insights incorporates scientific and systematic research procedures in order to get proper market insights and industry analysis for overall business success. The analysis consists of studying the market from a miniscule level wherein we implement statistical tools which helps us in examining the data with accuracy and precision. 

Our research reports feature both; quantitative and qualitative aspects for any market. Qualitative information for any market research process are fundamental because they reveal the customer needs and wants, usage and consumption for any product/service related to a specific industry. This in turn aids the marketers/investors in knowing certain perceptions of the customers. Qualitative research can enlighten about the different product concepts and designs along with unique service offering that in turn, helps define marketing problems and generate opportunities. On the other hand, quantitative research engages with the data collection process through interviews, e-mail interactions, surveys and pilot studies. Quantitative aspects for the market research are useful to validate the hypotheses generated during qualitative research method, explore empirical patterns in the data with the help of statistical tools, and finally make the market estimations.

The Brainy Insights offers comprehensive research and analysis, based on a wide assortment of factual insights gained through interviews with CXOs and global experts and secondary data from reliable sources. Our analysts and industry specialist assume vital roles in building up statistical tools and analysis models, which are used to analyse the data and arrive at accurate insights with exceedingly informative research discoveries. The data provided by our organization have proven precious to a diverse range of companies, facilitating them to address issues such as determining which products/services are the most appealing, whether or not customers use the product in the manner anticipated, the purchasing intentions of the market and many others.

Our research methodology encompasses an idyllic combination of primary and secondary initiatives. Key phases involved in this process are listed below:

MARKET RESEARCH PROCESS

Data Procurement:

The phase involves the gathering and collecting of market data and its related information with the help of different sources & research procedures.

The data procurement stage involves in data gathering and collecting through various data sources.

This stage involves in extensive research. These data sources includes:

Purchased Database: Purchased databases play a crucial role in estimating the market sizes irrespective of the domain. Our purchased database includes:

  • The organizational databases such as D&B Hoovers, and Bloomberg that helps us to identify the competitive scenario of the key market players/organizations along with the financial information.
  • Industry/Market databases such as Statista, and Factiva provides market/industry insights and deduce certain formulations. 
  • We also have contractual agreements with various reputed data providers and third party vendors who provide information which are not limited to:
    • Import & Export Data
    • Business Trade Information
    • Usage rates of a particular product/service on certain demographics mainly focusing on the unmet prerequisites

Primary Research: The Brainy Insights interacts with leading companies and experts of the concerned domain to develop the analyst team’s market understanding and expertise. It improves and substantiates every single data presented in the market reports. Primary research mainly involves in telephonic interviews, E-mail interactions and face-to-face interviews with the raw material providers, manufacturers/producers, distributors, & independent consultants. The interviews that we conduct provides valuable data on market size and industry growth trends prevailing in the market. Our organization also conducts surveys with the various industry experts in order to gain overall insights of the industry/market. For instance, in healthcare industry we conduct surveys with the pharmacists, doctors, surgeons and nurses in order to gain insights and key information of a medical product/device/equipment which the customers are going to usage. Surveys are conducted in the form of questionnaire designed by our own analyst team. Surveys plays an important role in primary research because surveys helps us to identify the key target audiences of the market. Additionally, surveys helps to identify the key target audience engaged with the market. Our survey team conducts the survey by targeting the key audience, thus gaining insights from them. Based on the perspectives of the customers, this information is utilized to formulate market strategies. Moreover, market surveys helps us to understand the current competitive situation of the industry. To be precise, our survey process typically involve with the 360 analysis of the market. This analytical process begins by identifying the prospective customers for a product or service related to the market/industry to obtain data on how a product/service could fit into customers’ lives.

Secondary Research: The secondary data sources includes information published by the on-profit organizations such as World bank, WHO, company fillings, investor presentations, annual reports, national government documents, statistical databases, blogs, articles, white papers and others. From the annual report, we analyse a company’s revenue to understand the key segment and market share of that organization in a particular region. We analyse the company websites and adopt the product mapping technique which is important for deriving the segment revenue. In the product mapping method, we select and categorize the products offered by the companies catering to domain specific market, deduce the product revenue for each of the companies so as to get overall estimation of the market size. We also source data and analyses trends based on information received from supply side and demand side intermediaries in the value chain. The supply side denotes the data gathered from supplier, distributor, wholesaler and the demand side illustrates the data gathered from the end customers for respective market domain.

The supply side for a domain specific market is analysed by:

  • Estimating and projecting penetration rates through analysing product attributes, availability of internal and external substitutes, followed by pricing analysis of the product.
  • Experiential assessment of year-on-year sales of the product by conducting interviews.

The demand side for the market is estimated through:

  • Evaluating the penetration level and usage rates of the product.
  • Referring to the historical data to determine the growth rate and evaluate the industry trends

In-house Library: Apart from these third-party sources, we have our in-house library of qualitative and quantitative information. Our in-house database includes market data for various industry and domains. These data are updated on regular basis as per the changing market scenario. Our library includes, historic databases, internal audit reports and archives.

Sometimes there are instances where there is no metadata or raw data available for any domain specific market. For those cases, we use our expertise to forecast and estimate the market size in order to generate comprehensive data sets. Our analyst team adopt a robust research technique in order to produce the estimates:

  • Applying demographic along with psychographic segmentation for market evaluation
  • Determining the Micro and Macro-economic indicators for each region 
  • Examining the industry indicators prevailing in the market. 

Data Synthesis: This stage involves the analysis & mapping of all the information obtained from the previous step. It also involves in scrutinizing the data for any discrepancy observed while data gathering related to the market. The data is collected with consideration to the heterogeneity of sources. Robust scientific techniques are in place for synthesizing disparate data sets and provide the essential contextual information that can orient market strategies. The Brainy Insights has extensive experience in data synthesis where the data passes through various stages:

  • Data Screening: Data screening is the process of scrutinising data/information collected from primary research for errors and amending those collected data before data integration method. The screening involves in examining raw data, identifying errors and dealing with missing data. The purpose of the data screening is to ensure data is correctly entered or not. The Brainy Insights employs objective and systematic data screening grades involving repeated cycles of quality checks, screening and suspect analysis.
  • Data Integration: Integrating multiple data streams is necessary to produce research studies that provide in-depth picture to the clients. These data streams come from multiple research studies and our in house database. After screening of the data, our analysts conduct creative integration of data sets, optimizing connections between integrated surveys and syndicated data sources. There are mainly 2 research approaches that we follow in order to integrate our data; top down approach and bottom up approach.

Market Deduction & Formulation: The final stage comprises of assigning data points at appropriate market spaces so as to deduce feasible conclusions. Analyst perspective & subject matter expert based holistic form of market sizing coupled with industry analysis also plays a crucial role in this stage.

This stage involves in finalization of the market size and numbers that we have collected from data integration step. With data interpolation, it is made sure that there is no gap in the market data. Successful trend analysis is done by our analysts using extrapolation techniques, which provide the best possible forecasts for the market.

Data Validation & Market Feedback: Validation is the most important step in the process. Validation & re-validation via an intricately designed process helps us finalize data-points to be used for final calculations.

The Brainy Insights interacts with leading companies and experts of the concerned domain to develop the analyst team’s market understanding and expertise. It improves and substantiates every single data presented in the market reports. The data validation interview and discussion panels are typically composed of the most experienced industry members. The participants include, however, are not limited to:

  • CXOs and VPs of leading companies’ specific to sector
  • Purchasing managers, technical personnel, end-users
  • Key opinion leaders such as investment bankers, and industry consultants

Moreover, we always validate our data and findings through primary respondents from all the major regions we are working on.

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