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The global protein engineering market was valued at USD 3.71 Billion in 2022, which is anticipated to grow at a CAGR of 16.25% from 2023 to 2032. Due to protein-based therapies' advantages over non-protein drugs, such as higher cost-effectiveness and better patient outcomes, biotechnology and pharmaceutical companies have increased their focus on the research and development of these therapies. Other factors contributing to the market growth include these advantages. Similarly, the adoption of protein engineering is driven by a rise in demand for customized medicines to treat cancer and autoimmune illnesses.
Protein engineering describes creating or altering a protein sequence for the desired outcome. It uses recombinant DNA technology to change amino acid sequences for new and improved functionalities, producing new proteins or modifying the existing structure or sequence. It is frequently used to produce proteins or enzymes in great quantities for industrial use. In recent years, the effective engineering of a wide variety of proteins for use in biotechnology, industry, health, and medicine has increased demand for these proteins globally. The two main reasons propelling market expansion are increasing investments in synthetic biology and a growing emphasis on developing protein-based drugs. In addition, because of the good clinical outcomes associated with protein treatments, there has been a major shift away from non-protein medications. The demand for protein engineering is rising as a result of this and the widespread prevalence of protein-deficient disorders. Additionally, a number of beneficial efforts implemented by the governments of various nations, such as increasing financing for research and development (R&D) activities in the area of protein engineering, are fostering the market's expansion. In addition, the development of recombinant monoclonal antibodies (mAbs) and the rising use of monoclonal antibodies in treating various illnesses, including cancer and autoimmune diseases, are speeding up the adoption of new products. Moreover, the development of the market is being fueled by continuous research into the use of protein engineering in the agrochemical sector to create enzymes with improved function and boost agricultural yields or facilitate the manufacture of biofuels. Other factors encouraging a favourable outlook for the market include the rising need for personalized medicines, the expanding requirement for biosimilars and biologics, improved healthcare systems, technical developments, and product innovations.
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Rising need for treatments and medications based on proteins- The market for protein engineering depends on the rising need for medications made of proteins. Biological products or medications based on proteins are utilized more frequently to treat illnesses like cancer, autoimmune conditions, and uncommon genetic disorders. Protein-based medications have various benefits over conventional small-molecule medications. Given that they are created to interact with particular bodily targets, they are frequently more focused and cause fewer side effects. Additionally, protein-based medications have a lower likelihood of being metabolized by the liver, which can increase their effectiveness and lower the likelihood of toxicity. The demand for protein-based medicines has expanded substantially due to these benefits. Several variables, including ageing populations, rising healthcare costs, and an increase in the prevalence of chronic diseases, influence this expansion. Demand for novel and better therapies is mostly being driven by the rising prevalence of chronic diseases like cancer, diabetes, and cardiovascular conditions. "personalized medicine" refers to adapting a patient's medical care to their unique genetic profile or other characteristics, such as age, gender, and lifestyle choices. Protein engineering plays a significant part in advancing personalized medicine by enabling the development of proteins specifically suited to patient requirements. For instance, monoclonal antibodies that target specific cancer cells while protecting healthy cells from harm are frequently used in cancer treatment. Protein engineering can make monoclonal antibodies more potent and selective, increasing their usefulness and minimizing negative effects. By designing personalized cancer treatments specifically suited to each patient's genetic profile, doctors improve patient outcomes and lower healthcare costs. Protein engineering is becoming more popular as the healthcare sector approaches personalized therapy. As a result, businesses invest in R&D to develop cutting-edge protein-based treatments unique to each patient, fueling growth in the protein engineering market.
High development costs- Protein engineering includes complicated and tedious designing, synthesis, and testing proteins with specific characteristics. A significant barrier to entry for smaller businesses and startups is the requirement for substantial investments in research and development in this process. Indirect expenses are related to bringing protein-based products to market in addition to direct expenditures for research and development. For instance, the lengthy and expensive regulatory approval process for new protein-based medications includes numerous clinical trials and comprehensive safety assessments. Since smaller businesses and startups lack funds to spend on research and development, protein engineering's high development costs have an adverse impact on market competition. As a result, larger corporations' market power becomes concentrated, discouraging innovation and raising consumer prices.
Technological advances in synthetic biology and gene editing- By modifying and reprogramming the genetic code of cells, gene editing and synthetic biology technologies allow scientists to produce novel proteins with distinctive features. Using CRISPR/Cas9 gene editing technologies to change the genes that code for particular proteins is one potential field of research. Researchers have the potential to selectively modify these genes to produce proteins with novel or enhanced functionalities, such as higher stability, improved selectivity, or improved activity. New possibilities for protein engineering are provided by synthetic biology. Utilizing DNA and other biological building blocks, synthetic biology involves building new biological systems. Scientists use synthetic biology techniques to make new proteins or change existing ones to fulfil specific needs. For instance, using synthetic biology, scientists have created proteins that can recognize and react to various environmental factors, such as temperature changes or particular chemicals. These proteins might be used for everything from medication delivery to environmental monitoring. Consequently, gene editing and synthetic biology developments will encourage innovation in the protein engineering field and lead to the development of novel, enhanced protein-based products with various uses in industry, agriculture, and healthcare.
The regions analyzed for the market include North America, Europe, South America, Asia Pacific, the Middle East, and Africa. North America emerged as the most significant global protein engineering market, with a 36.43% market revenue share in 2022. The geographical region is anticipated to maintain its leadership for the forecasted period. The increased share acquired by this area is likely due to the growing number of collaborations promoted by major market players for enhancing their R&D skills.
North America Region Protein Engineering Market Share in 2022 - 36.43%
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The product segment is divided into reagents, instruments, and software & services. The instruments segment dominated the market, with a market share of around 34.06% in 2022. One of the key reasons fueling segment growth is the growing preference among researchers for automated methods for encouraging quick molecular development processes. Furthermore, the segment's growth will likely be supported throughout the projected period by increased demand for high-efficiency protein engineering tools such as real-time PCR equipment and chromatographic systems.
The technology segment is divided into directed evolution, de novo protein design, rational protein design, hybrid approach, and others. The rational protein design segment dominated the market, with a market share of around 22.81% in 2022. The technology's vast application in the production of antibodies and enzyme engineering accounts for the dominant share. Enzymes that have been improved and modified to have the appropriate catalytic capabilities have been created due to the significant growth in commercial applications of enzyme engineering. Site-directed mutagenesis is one technique that is often utilized in rational design engineering approaches, and the significant market penetration of such techniques drives the segment.
The protein type segment is divided into monoclonal antibodies, growth factors, coagulation factors, insulin, colony stimulating factors, vaccines, interferon, and others. The monoclonal antibodies segment dominated the market, with a market share of around 14.11% in 2022. The increasing R&D expenditures for creating therapeutically improved monoclonal antibodies are one of the primary factors influencing the increased utilization of these technologies. Additionally, the market is anticipated to grow soon as customized monoclonal antibodies are used to treat cancer and other chronic diseases. Similar to this, it is anticipated that the growth potential will further increase with the introduction of genetic platforms that use cutting-edge technology, such as next-generation sequencing, which makes it possible to efficiently create proteins to produce monoclonal antibodies.
Report Description:
| Attribute | Description |
|---|---|
| Market Size | Revenue (USD Billion) |
| Market size value in 2022 | USD 3.71 Billion |
| Market size value in 2032 | USD 16.72 Billion |
| CAGR (2023 to 2032) | 16.25% |
| Historical data | 2019-2021 |
| Base Year | 2022 |
| Forecast | 2023-2032 |
| Region | The regions analyzed for the market are Asia Pacific, Europe, South America, North America, and Middle East & Africa. Furthermore, the regions are further analyzed at the country level. |
| Segments | Product, Technology, Protein Type |
As per The Brainy Insights, the size of the protein engineering market was valued at USD 3.71 Billion in 2022 & USD 16.72 Billion by 2032.
Global protein engineering market is growing at a CAGR of 16.25% during the forecast period 2023-2032.
North America region emerged as the largest market for the protein engineering.
Rising need for treatments and medications based on proteins is a significant driving factor for the growth of the protein engineering market.
High development cost is a significant restraining factor for the growth of the protein engineering market.
Technological advancement in synthetic biology and gene editing is a significant opportunity for the growth of the protein engineering market.
Key players are Bruker Cor., PerkinElmer, Inc., Bio-Rad Laboratories, Danaher Corp., Amgen, Inc., Agilent Technologies, Waters Corp., Genscript Biotech Corp., Thermo Fisher Scientific, Inc., Merck KGaA, among others.
1. Introduction
1.1. Objective of the Study
1.2. Market Definition
1.3. Research Scope
1.4. Currency
1.5. Key Target Audience
2. Research Methodology and Assumptions
3. Executive Summary
4. Premium Insights
4.1. Porter’s Five Forces Analysis
4.2. Value Chain Analysis
4.3. Top Investment Pockets
4.3.1. Market Attractiveness Analysis By Product
4.3.2. Market Attractiveness Analysis By Technology
4.3.3. Market Attractiveness Analysis By Protein Type
4.3.4. Market Attractiveness Analysis By Region
4.4. Industry Trends
5. Market Dynamics
5.1. Market Evaluation
5.2. Drivers
5.2.1. Rising need for treatments and medications based on proteins
5.3. Restraints
5.3.1. High development costs
5.4. Opportunities
5.4.1. Technological advances in synthetic biology and gene editing
6. Global Protein Engineering Market Analysis and Forecast, By Product
6.1. Segment Overview
6.2. Reagents
6.3. Instruments
6.4. Software & Services
7. Global Protein Engineering Market Analysis and Forecast, By Technology
7.1. Segment Overview
7.2. Directed Evolution
7.3. De Novo Protein Design
7.4. Rational Protein Design
7.5. Hybrid Approach
7.6. Others
8. Global Protein Engineering Market Analysis and Forecast, By Protein Type
8.1. Segment Overview
8.2. Monoclonal Antibodies
8.3. Growth Factors
8.4. Coagulation Factors
8.5. Insulin
8.6. Colony Stimulating Factors
8.7. Vaccines
8.8. Interferon
8.9. Others
9. Global Protein Engineering Market Analysis and Forecast, By Regional Analysis
9.1. Segment Overview
9.2. North America
9.2.1. U.S.
9.2.2. Canada
9.2.3. Mexico
9.3. Europe
9.3.1. Germany
9.3.2. France
9.3.3. U.K.
9.3.4. Italy
9.3.5. Spain
9.4. Asia-Pacific
9.4.1. Japan
9.4.2. China
9.4.3. India
9.5. South America
9.5.1. Brazil
9.6. Middle East and Africa
9.6.1. UAE
9.6.2. South Africa
10. Global Protein Engineering Market-Competitive Landscape
10.1. Overview
10.2. Market Share of Key Players in the Protein Engineering Market
10.2.1. Global Company Market Share
10.2.2. North America Company Market Share
10.2.3. Europe Company Market Share
10.2.4. APAC Company Market Share
10.3. Competitive Situations and Trends
10.3.1. Product Launches and Developments
10.3.2. Partnerships, Collaborations, and Agreements
10.3.3. Mergers & Acquisitions
10.3.4. Expansions
11. Company Profiles
11.1. Bruker Cor.
11.1.1. Business Overview
11.1.2. Company Snapshot
11.1.3. Company Market Share Analysis
11.1.4. Company Product Portfolio
11.1.5. Recent Developments
11.1.6. SWOT Analysis
11.2. PerkinElmer, Inc.
11.2.1. Business Overview
11.2.2. Company Snapshot
11.2.3. Company Market Share Analysis
11.2.4. Company Product Portfolio
11.2.5. Recent Developments
11.2.6. SWOT Analysis
11.3. Bio-Rad Laboratories
11.3.1. Business Overview
11.3.2. Company Snapshot
11.3.3. Company Market Share Analysis
11.3.4. Company Product Portfolio
11.3.5. Recent Developments
11.3.6. SWOT Analysis
11.4. Danaher Corp.
11.4.1. Business Overview
11.4.2. Company Snapshot
11.4.3. Company Market Share Analysis
11.4.4. Company Product Portfolio
11.4.5. Recent Developments
11.4.6. SWOT Analysis
11.5. Amgen, Inc.
11.5.1. Business Overview
11.5.2. Company Snapshot
11.5.3. Company Market Share Analysis
11.5.4. Company Product Portfolio
11.5.5. Recent Developments
11.5.6. SWOT Analysis
11.6. Agilent Technologies
11.6.1. Business Overview
11.6.2. Company Snapshot
11.6.3. Company Market Share Analysis
11.6.4. Company Product Portfolio
11.6.5. Recent Developments
11.6.6. SWOT Analysis
11.7. Waters Corp.
11.7.1. Business Overview
11.7.2. Company Snapshot
11.7.3. Company Market Share Analysis
11.7.4. Company Product Portfolio
11.7.5. Recent Developments
11.7.6. SWOT Analysis
11.8. Genscript Biotech Corp.
11.8.1. Business Overview
11.8.2. Company Snapshot
11.8.3. Company Market Share Analysis
11.8.4. Company Product Portfolio
11.8.5. Recent Developments
11.8.6. SWOT Analysis
11.9. Thermo Fisher Scientific, Inc.
11.9.1. Business Overview
11.9.2. Company Snapshot
11.9.3. Company Market Share Analysis
11.9.4. Company Product Portfolio
11.9.5. Recent Developments
11.9.6. SWOT Analysis
11.10. Merck KGaA
11.10.1. Business Overview
11.10.2. Company Snapshot
11.10.3. Company Market Share Analysis
11.10.4. Company Product Portfolio
11.10.5. Recent Developments
11.10.6. SWOT Analysis
List of Table
1. Global Protein Engineering Market, By Product, 2019-2032 (USD Billion)
2. Global Reagents, Protein Engineering Market, By Region, 2019-2032 (USD Billion)
3. Global Instruments, Protein Engineering Market, By Region, 2019-2032 (USD Billion)
4. Global Software & Services, Protein Engineering Market, By Region, 2019-2032 (USD Billion)
5. Global Protein Engineering Market, By Technology, 2019-2032 (USD Billion)
6. Global Directed Evolution, Protein Engineering Market, By Region, 2019-2032 (USD Billion)
7. Global De Novo Protein Design, Protein Engineering Market, By Region, 2019-2032 (USD Billion)
8. Global Rational Protein Design, Protein Engineering Market, By Region, 2019-2032 (USD Billion)
9. Global Hybrid Approach, Protein Engineering Market, By Region, 2019-2032 (USD Billion)
10. Global Others, Protein Engineering Market, By Region, 2019-2032 (USD Billion)
11. Global Protein Engineering Market, By Protein Type, 2019-2032 (USD Billion)
12. Global Monoclonal Antibodies, Protein Engineering Market, By Region, 2019-2032 (USD Billion)
13. Global Growth Factors, Protein Engineering Market, By Region, 2019-2032 (USD Billion)
14. Global Coagulation Factors, Protein Engineering Market, By Region, 2019-2032 (USD Billion)
15. Global Insulin, Protein Engineering Market, By Region, 2019-2032 (USD Billion)
16. Global Colony Stimulating Factors, Protein Engineering Market, By Region, 2019-2032 (USD Billion)
17. Global Vaccines, Protein Engineering Market, By Region, 2019-2032 (USD Billion)
18. Global Interferon, Protein Engineering Market, By Region, 2019-2032 (USD Billion)
19. Global Others, Protein Engineering Market, By Region, 2019-2032 (USD Billion)
20. Global Protein Engineering Market, By Region, 2019-2032 (USD Billion)
21. North America Protein Engineering Market, By Product, 2019-2032 (USD Billion)
22. North America Protein Engineering Market, By Technology, 2019-2032 (USD Billion)
23. North America Protein Engineering Market, By Protein Type, 2019-2032 (USD Billion)
24. U.S. Protein Engineering Market, By Product, 2019-2032 (USD Billion)
25. U.S. Protein Engineering Market, By Technology, 2019-2032 (USD Billion)
26. U.S. Protein Engineering Market, By Protein Type, 2019-2032 (USD Billion)
27. Canada Protein Engineering Market, By Product, 2019-2032 (USD Billion)
28. Canada Protein Engineering Market, By Technology, 2019-2032 (USD Billion)
29. Canada Protein Engineering Market, By Protein Type, 2019-2032 (USD Billion)
30. Mexico Protein Engineering Market, By Product, 2019-2032 (USD Billion)
31. Mexico Protein Engineering Market, By Technology, 2019-2032 (USD Billion)
32. Mexico Protein Engineering Market, By Protein Type, 2019-2032 (USD Billion)
33. Europe Protein Engineering Market, By Product, 2019-2032 (USD Billion)
34. Europe Protein Engineering Market, By Technology, 2019-2032 (USD Billion)
35. Europe Protein Engineering Market, By Protein Type, 2019-2032 (USD Billion)
36. Germany Protein Engineering Market, By Product, 2019-2032 (USD Billion)
37. Germany Protein Engineering Market, By Technology, 2019-2032 (USD Billion)
38. Germany Protein Engineering Market, By Protein Type, 2019-2032 (USD Billion)
39. France Protein Engineering Market, By Product, 2019-2032 (USD Billion)
40. France Protein Engineering Market, By Technology, 2019-2032 (USD Billion)
41. France Protein Engineering Market, By Protein Type, 2019-2032 (USD Billion)
42. U.K. Protein Engineering Market, By Product, 2019-2032 (USD Billion)
43. U.K. Protein Engineering Market, By Technology, 2019-2032 (USD Billion)
44. U.K. Protein Engineering Market, By Protein Type, 2019-2032 (USD Billion)
45. Italy Protein Engineering Market, By Product, 2019-2032 (USD Billion)
46. Italy Protein Engineering Market, By Technology, 2019-2032 (USD Billion)
47. Italy Protein Engineering Market, By Protein Type, 2019-2032 (USD Billion)
48. Spain Protein Engineering Market, By Product, 2019-2032 (USD Billion)
49. Spain Protein Engineering Market, By Technology, 2019-2032 (USD Billion)
50. Spain Protein Engineering Market, By Protein Type, 2019-2032 (USD Billion)
51. Asia Pacific Protein Engineering Market, By Product, 2019-2032 (USD Billion)
52. Asia Pacific Protein Engineering Market, By Technology, 2019-2032 (USD Billion)
53. Asia Pacific Protein Engineering Market, By Protein Type, 2019-2032 (USD Billion)
54. Japan Protein Engineering Market, By Product, 2019-2032 (USD Billion)
55. Japan Protein Engineering Market, By Technology, 2019-2032 (USD Billion)
56. Japan Protein Engineering Market, By Protein Type, 2019-2032 (USD Billion)
57. China Protein Engineering Market, By Product, 2019-2032 (USD Billion)
58. China Protein Engineering Market, By Technology, 2019-2032 (USD Billion)
59. China Protein Engineering Market, By Protein Type, 2019-2032 (USD Billion)
60. India Protein Engineering Market, By Product, 2019-2032 (USD Billion)
61. India Protein Engineering Market, By Technology, 2019-2032 (USD Billion)
62. India Protein Engineering Market, By Protein Type, 2019-2032 (USD Billion)
63. South America Protein Engineering Market, By Product, 2019-2032 (USD Billion)
64. South America Protein Engineering Market, By Technology, 2019-2032 (USD Billion)
65. South America Protein Engineering Market, By Protein Type, 2019-2032 (USD Billion)
66. Brazil Protein Engineering Market, By Product, 2019-2032 (USD Billion)
67. Brazil Protein Engineering Market, By Technology, 2019-2032 (USD Billion)
68. Brazil Protein Engineering Market, By Protein Type, 2019-2032 (USD Billion)
69. Middle East and Africa Protein Engineering Market, By Product, 2019-2032 (USD Billion)
70. Middle East and Africa Protein Engineering Market, By Technology, 2019-2032 (USD Billion)
71. Middle East and Africa Protein Engineering Market, By Protein Type, 2019-2032 (USD Billion)
72. UAE Protein Engineering Market, By Product, 2019-2032 (USD Billion)
73. UAE Protein Engineering Market, By Technology, 2019-2032 (USD Billion)
74. UAE Protein Engineering Market, By Protein Type, 2019-2032 (USD Billion)
75. South Africa Protein Engineering Market, By Product, 2019-2032 (USD Billion)
76. South Africa Protein Engineering Market, By Technology, 2019-2032 (USD Billion)
77. South Africa Protein Engineering Market, By Protein Type, 2019-2032 (USD Billion)
List of Figures
1. Global Protein Engineering Market Segmentation
2. Protein Engineering Market: Research Methodology
3. Market Size Estimation Methodology: Bottom-Up Approach
4. Market Size Estimation Methodology: Top-Down Approach
5. Data Triangulation
6. Porter’s Five Forces Analysis
7. Value Chain Analysis
8. Global Protein Engineering Market Attractiveness Analysis By Product
9. Global Protein Engineering Market Attractiveness Analysis By Technology
10. Global Protein Engineering Market Attractiveness Analysis By Protein Type
11. Global Protein Engineering Market Attractiveness Analysis By Region
12. Global Protein Engineering Market: Dynamics
13. Global Protein Engineering Market Share By Product (2023 & 2032)
14. Global Protein Engineering Market Share By Technology (2023 & 2032)
15. Global Protein Engineering Market Share by Protein Type (2023 & 2032)
16. Global Protein Engineering Market Share by Regions (2023 & 2032)
17. Global Protein Engineering Market Share by Company (2022)
This study forecasts revenue at global, regional, and country levels from 2019 to 2032. The Brainy Insights has segmented the global protein engineering market based on below mentioned segments:
Global Protein Engineering by Product:
Global Protein Engineering by Technology:
Global Protein Engineering by Protein Type:
Global Protein Engineering by Region:
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