Controlled Release Drug Delivery Market

Controlled Release Drug Delivery Market Size by Technology (Microencapsulation, Transdermal, Targeted delivery, and Others), By Release Mechanism ((Polymer Based Systems, Micro Reservoir Partition Controlled Drug Delivery Systems, Feedback Regulated Drug Delivery Systems, Activation-modulated Drug Delivery Systems, and Chemically Activated), By Application (Metered Dose Inhalers, Injectable, Transdermal, Oral Drug Delivery and Others), Regions, Global Industry Analysis, Share, Growth, Trends, and Forecast 2023 to 2032

Base Year: 2022 Historical Data: 2019-21
  • Report ID: TBI-13872
  • Published Date: Dec, 2023
  • Pages: 238
  • Category: Healthcare
  • Format: PDF
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The global controlled release drug delivery market was valued at USD 47.97 billion in 2022 and is anticipated to grow at a CAGR of 8.5% from 2023 to 2032. Controlled rеlеasе drug delivery refers to a dosage that aids in a drug's or medication's predefined rеlеasе. This drug delivery technique allows pharmaceuticals or drugs to be continuously delivered for a prescribed amount of time with predictable kinetics during the gastrointestinal transit. The medication is infused into the gastrointestinal tract until it reaches the desired duration. Drug encapsulating devices are used in control release drug delivery procedures to release the drug or medication at a controlled rate over extended periods, from days to months. A controlled rеlеasе drug delivery system has several benefits, such as improved medication stability, reduced dosage requirements, fewer adverse effects, improved patient compliance, improved drug safety and efficacy, and improved bioavailability.

Market Introduction:

The term “controlled release drug delivery” describes a highly developed and calculated pharmacological technique that aims to control the release of therapeutic substances into the human body over a prolonged length of time. This approach differs from traditional medication delivery methods, which usually entail the active pharmacological ingredient (API) being released quickly and instantly. By delivering a sustained and regulated level of medication, controlled-release drug delivery aims to maximize therapeutic efficacy, improve patient compliance, and reduce symptoms. One of its main advantages is the capacity of controlled-release drug delivery to sustain therapeutic drug concentrations for a prolonged period within the intended range. This aspect is in contrast to conventional drug formulations, which frequently cause drug levels to fluctuate and may result in adverse effects or less-than-ideal therapeutic outcomes. The goal of controlled release is to achieve a more stable and long-lasting drug release in the body, which can be especially helpful for long-term diseases that require constant therapy. To accomplish controlled relationships, various technologies and methods are used, each specifically designed to meet the patient's therapeutic needs and the medicine's unique characteristics. A popular strategy is using specially designed drug delivery systems, such as matrix, reservoir, and osmotic systems. These systems are designed to control the kinematics of drug release, limiting variations in plasma concentrations and guaranteeing consistent and effective delivery.

Controlled Release Drug Delivery Market Size

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Recent Development
  • In November 2021: Pfizer declared that it had acquired Trillium Therapeutics, a clinical-stage immuno-oncology business specializing in creating cutting-edge cancer therapy medicines. This acquisition is anticipated to fortify Pfizer's position in the controlled-release medication delivery market and expand its oncology portfolio.
  • In November 2023: The nasal delivery of potentiated oxytocin TNX-1900 from Tonix Pharmaceuticals is being tested at Massachusetts General Hospital to treat continuous eating disorders. Tonix is developing TNX-1900 to treat chronic migraines.

Market Dynamics:

Drivers

Increasing Incidences of Chronic Diseases - The rising global incidence of chronic illnesses is one of the main market drivers. Chronic illnesses that necessitate long-term, frequently life-threatening pharmacological use include diabetes, cardiovascular diseases, and neurological disorders. Systems for delivering drugs with controlled release present a calculated approach to overcoming the difficulties involved in controlling long-term conditions. These systems improve patient compliance and aid in better illness management by delivering a prolonged and regular delivery of drugs. The need for controlled drug delivery to ensure efficient and patient-friendly treatment regimens is highlighted by the rising incidence of chronic diseases and the world's ageing population. This is the primary factor for the market growth and development.

Restraints:

Stringent Regulatory Environment - One significant obstacle facing the market for controlled drug delivery is the regulatory environment. Pharmaceutical product approval is subject to strict restrictions set by regulatory bodies, including the European Medicines Agency (EMA) and the U.S. Food and Drug Administration (FDA). Strict examination of safety, effectiveness, and quality characteristics is required when evaluating formulations with controlled reliability. It takes significant financial resources for clinical and clinical research to navigate the regulatory process for these novel systems, which frequently prolongs the time it takes for market approval. The dynamic regulatory environment introduces an element of uncontrollable shifting policies and strategies that could affect the schedules for controlled product development and market growth. This factor is limiting the market growth and development.

Opportunities:

Growing Research & Development Activities Within the Pharmaceutical Industry - The market for controlled-release drug delivery is growing due to the pharmaceutical industry's increased emphasis on R&D. Businesses are making large investments in identifying and creating novel therapeutic agents, focusing on enhancing drug delivery to improve patient outcomes and efficacy. Consequentially, a significant pipeline of controlled-release formulations is being developed in various therapeutic areas, such as neurology, gastrointestinal, oncology, and pain management. The controlled delivery drug delivery industry is growing and becoming more competitive due to the constant stream of new medications and formulations hitting the market.

Regional segmentation analysis:

The regions analyzed for the market include North America, Europe, South America, Asia Pacific, the Middle East, and Africa. North America region emerged as the most prominent global Controlled release drug delivery market, with a 41.0% market revenue share in 2022. U.S., Canada and Mexico are the key countries contributing towards the regional market growth and development. The regional market dynamics are significantly shaped by the regulatory landscape in North America, which is controlled by the United States Food and Drug Administration (FDA). Controlled rеlеasе drug formulations must satisfy strict requirements set forth by the FDA for safety, efficacy, and quality before they may be sold. Although regulatory procedures are difficult, they also uphold the legitimacy and quality of goods, fostering trust among consumers and healthcare providers. Further, the high frequency of chronic illnesses in North America contributes to the demand for formulations with controlled reliability and long half-lives. The region has a large market for sustained-release drug delivery systems because of the prevalence of conditions like diabetes, cardiovascular diseases, and neurological disorders. The demand for efficient and patient-friendly transportation choices is heightened by North America's ageing population, which aligns with the potential of controlled-release drug technology. The regional market players also engage in various market strategies such as product innovation, product differentiation, mergers, acquisitions, partnerships, and strategic alliances to maintain their competitive edge.

North America Region Controlled release drug delivery Market Share in 2022 - 41.0%

 

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  • In February 2022: Evonik introduced a novel microparticle technology called Eudratec SoluFlow to improve the solubility of active medicinal components in oral medication formulations. Eudratec SoluFlow makes it possible to develop novel oral medicines for various conditions, including diabetes, cancer, cardiovascular disease, and infectious diseases, since over 70% of newly discovered small compounds are insoluble.
  • In September 2020: Sanofi acquired Principia Biopharma Inc.; a clinical-stage biopharmaceutical business focused on creating advanced treatments for immune-mediated illnesses. Sanofi is anticipated to benefit from this acquisition by strengthening its drug delivery capabilities and growing its market share in the global controlled-release drug delivery market.
Technology Segment Analysis

The technology segment includes micro encapsulation, transdermal, targeted delivery, and others. The targeted delivery segment dominated, with a market share of around 34% in 2022. The potential of targeted drug delivery to raise a medication's therapeutic index is one of the main factors driving its market share. Targeted delivery reduces side effects by delivering drugs to the site of action, enabling the use of larger drug concentrations at the intended site. This is especially important when treating cancer since targeted delivery systems aim to increase the effectiveness of chemotherapy drugs. Targeted drug delivery is made possible by nanotechnology, which makes it possible to create micelles, liposomes, and nanoparticles that can pass through biological barriers and encapsulate medications. Targeting precision is further improved by ligands, antibodies, or peptides that identify particular receptors or markers on sick cells.

Application Segment Analysis

The application segment is bifurcated into metered dose inhalers, injectable, transdermal, oral drug delivery and others. The oral drug delivery segment dominated, with a market share of around 38% in 2022. The oral route, which includes tablets, capsules, and other solid dosage forms, is the most widely used and recognized method of medication administration. To meet a variety of therapeutic demands, controlled rеlеasе formulations for oral drug delivery offer flexibility in creating drug rеlеasе profiles that include immediate rеlеasе, delayed rеlеasе, and sustained rеlеasе. Oral drug administration has a marked effect on many therapeutic areas, such as chronic diseases, pain treatment, and cardiovascular health. Pharmaceutical formulation science advances like multiarticulate and gastrorеtеntivе systems help optimize medication rеlеasе kinetics and absorption.  

Release Mechanism Segment Analysis

The release mechanism segment is bifurcated into polymer-based systems, micro reservoir partition-controlled drug delivery systems, feedback regulated drug delivery systems, activation-modulated drug delivery systems, and chemically activated. The feedback regulated drug delivery systems segment dominated, with a market share of around 32% in 2022. The ability of fееdback-regulated drug delivery systems to handle the dynamic nature of physiological situations is one of the main factors driving their market share. These technologies allow the drug delivery system to incorporate sensors or sensory parts to monitor parameters like pH, glucose levels, or concentrations of biomarkers. The feedback loop then causes modifications to the drug's receptor, guaranteeing the maintenance of therapeutic levels. Fееdback regulated drug delivery systems have a market share in several therapeutic areas, such as neurology, oncology, and diabetes treatment. For diabetics, for instance, insulin can be delivered and regulated via devices that react to variations in glucose levels, simulating the body's natural control over blood sugar. This method improves patient outcomes and improves drug delivery methods.

Some of the Key Market Players:
  • Depomed, Inc.
  • Coating Place, Inc.
  • Corium International, Inc.
  • Johnson and Johnson Services, Inc.
  • Alkermes plc
  • Pfizer, Inc.
  • Orbis Biosciences, Inc.
  • Capsugel
  • Merck and Co., Inc.
  • Aradigm Corporation.

Report Description: 

Attribute Description
Market Size Revenue (USD Billion)
Market size value in 2022 USD 47.97 Billion
Market size value in 2032 USD 108.45 Billion
CAGR (2023 to 2032) 8.5%
Historical data 2019-2021
Base Year 2022
Forecast 2023-2032
Region The regions analyzed for the market are Asia Pacific, Europe, South America, North America, and Middle East & Africa. Furthermore, the regions are further analyzed at the country level.
Segments Technology, Application, Release Mechanism

Frequesntly Asked Questions

As per The Brainy Insights, the size of the Controlled release drug delivery market was valued at 47.97 billion in 2022 to USD 108.45 billion by 2032.

The global Controlled release drug delivery market is growing at a CAGR of 8.5% during the forecast period 2023-2032.

North America region became the largest market for Controlled release drug delivery.

The rising demand for personalized medicine is influencing the market's growth.

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This study forecasts revenue at global, regional, and country levels from 2019 to 2032. The Brainy Insights has segmented the global controlled release drug delivery market based on below-mentioned segments:

Global Controlled Release Drug Delivery Market by Technology:

  • Micro Encapsulation  
  • Transdermal  
  • Targeted delivery  
  • Other Technologies

Global Controlled Release Drug Delivery Market by Application:

  • Metered Dose Inhalers  
  • Injectable 
  • Transdermal
  • Oral Drug Delivery
  • Others

Global Controlled Release Drug Delivery Market by Release Mechanism:

  • Polymer Based Systems
  • Micro Reservoir Partition Controlled Drug Delivery Systems
  • Feedback Regulated Drug Delivery Systems
  • Activation-modulated Drug Delivery Systems
  • Chemically Activated

Global Controlled Release Drug Delivery Market by Region:

  • North America
    • U.S.
    • Canada
    • Mexico
  • Europe
    • Germany
    • France
    • U.K.
    • Italy
    • Spain
  • Asia-Pacific
    • Japan
    • China
    • India
  • South America
    • Brazil
  • Middle East and Africa  
    • UAE
    • South Africa

Methodology

Research has its special purpose to undertake marketing efficiently. In this competitive scenario, businesses need information across all industry verticals; the information about customer wants, market demand, competition, industry trends, distribution channels etc. This information needs to be updated regularly because businesses operate in a dynamic environment. Our organization, The Brainy Insights incorporates scientific and systematic research procedures in order to get proper market insights and industry analysis for overall business success. The analysis consists of studying the market from a miniscule level wherein we implement statistical tools which helps us in examining the data with accuracy and precision. 

Our research reports feature both; quantitative and qualitative aspects for any market. Qualitative information for any market research process are fundamental because they reveal the customer needs and wants, usage and consumption for any product/service related to a specific industry. This in turn aids the marketers/investors in knowing certain perceptions of the customers. Qualitative research can enlighten about the different product concepts and designs along with unique service offering that in turn, helps define marketing problems and generate opportunities. On the other hand, quantitative research engages with the data collection process through interviews, e-mail interactions, surveys and pilot studies. Quantitative aspects for the market research are useful to validate the hypotheses generated during qualitative research method, explore empirical patterns in the data with the help of statistical tools, and finally make the market estimations.

The Brainy Insights offers comprehensive research and analysis, based on a wide assortment of factual insights gained through interviews with CXOs and global experts and secondary data from reliable sources. Our analysts and industry specialist assume vital roles in building up statistical tools and analysis models, which are used to analyse the data and arrive at accurate insights with exceedingly informative research discoveries. The data provided by our organization have proven precious to a diverse range of companies, facilitating them to address issues such as determining which products/services are the most appealing, whether or not customers use the product in the manner anticipated, the purchasing intentions of the market and many others.

Our research methodology encompasses an idyllic combination of primary and secondary initiatives. Key phases involved in this process are listed below:

MARKET RESEARCH PROCESS

Data Procurement:

The phase involves the gathering and collecting of market data and its related information with the help of different sources & research procedures.

The data procurement stage involves in data gathering and collecting through various data sources.

This stage involves in extensive research. These data sources includes:

Purchased Database: Purchased databases play a crucial role in estimating the market sizes irrespective of the domain. Our purchased database includes:

  • The organizational databases such as D&B Hoovers, and Bloomberg that helps us to identify the competitive scenario of the key market players/organizations along with the financial information.
  • Industry/Market databases such as Statista, and Factiva provides market/industry insights and deduce certain formulations. 
  • We also have contractual agreements with various reputed data providers and third party vendors who provide information which are not limited to:
    • Import & Export Data
    • Business Trade Information
    • Usage rates of a particular product/service on certain demographics mainly focusing on the unmet prerequisites

Primary Research: The Brainy Insights interacts with leading companies and experts of the concerned domain to develop the analyst team’s market understanding and expertise. It improves and substantiates every single data presented in the market reports. Primary research mainly involves in telephonic interviews, E-mail interactions and face-to-face interviews with the raw material providers, manufacturers/producers, distributors, & independent consultants. The interviews that we conduct provides valuable data on market size and industry growth trends prevailing in the market. Our organization also conducts surveys with the various industry experts in order to gain overall insights of the industry/market. For instance, in healthcare industry we conduct surveys with the pharmacists, doctors, surgeons and nurses in order to gain insights and key information of a medical product/device/equipment which the customers are going to usage. Surveys are conducted in the form of questionnaire designed by our own analyst team. Surveys plays an important role in primary research because surveys helps us to identify the key target audiences of the market. Additionally, surveys helps to identify the key target audience engaged with the market. Our survey team conducts the survey by targeting the key audience, thus gaining insights from them. Based on the perspectives of the customers, this information is utilized to formulate market strategies. Moreover, market surveys helps us to understand the current competitive situation of the industry. To be precise, our survey process typically involve with the 360 analysis of the market. This analytical process begins by identifying the prospective customers for a product or service related to the market/industry to obtain data on how a product/service could fit into customers’ lives.

Secondary Research: The secondary data sources includes information published by the on-profit organizations such as World bank, WHO, company fillings, investor presentations, annual reports, national government documents, statistical databases, blogs, articles, white papers and others. From the annual report, we analyse a company’s revenue to understand the key segment and market share of that organization in a particular region. We analyse the company websites and adopt the product mapping technique which is important for deriving the segment revenue. In the product mapping method, we select and categorize the products offered by the companies catering to domain specific market, deduce the product revenue for each of the companies so as to get overall estimation of the market size. We also source data and analyses trends based on information received from supply side and demand side intermediaries in the value chain. The supply side denotes the data gathered from supplier, distributor, wholesaler and the demand side illustrates the data gathered from the end customers for respective market domain.

The supply side for a domain specific market is analysed by:

  • Estimating and projecting penetration rates through analysing product attributes, availability of internal and external substitutes, followed by pricing analysis of the product.
  • Experiential assessment of year-on-year sales of the product by conducting interviews.

The demand side for the market is estimated through:

  • Evaluating the penetration level and usage rates of the product.
  • Referring to the historical data to determine the growth rate and evaluate the industry trends

In-house Library: Apart from these third-party sources, we have our in-house library of qualitative and quantitative information. Our in-house database includes market data for various industry and domains. These data are updated on regular basis as per the changing market scenario. Our library includes, historic databases, internal audit reports and archives.

Sometimes there are instances where there is no metadata or raw data available for any domain specific market. For those cases, we use our expertise to forecast and estimate the market size in order to generate comprehensive data sets. Our analyst team adopt a robust research technique in order to produce the estimates:

  • Applying demographic along with psychographic segmentation for market evaluation
  • Determining the Micro and Macro-economic indicators for each region 
  • Examining the industry indicators prevailing in the market. 

Data Synthesis: This stage involves the analysis & mapping of all the information obtained from the previous step. It also involves in scrutinizing the data for any discrepancy observed while data gathering related to the market. The data is collected with consideration to the heterogeneity of sources. Robust scientific techniques are in place for synthesizing disparate data sets and provide the essential contextual information that can orient market strategies. The Brainy Insights has extensive experience in data synthesis where the data passes through various stages:

  • Data Screening: Data screening is the process of scrutinising data/information collected from primary research for errors and amending those collected data before data integration method. The screening involves in examining raw data, identifying errors and dealing with missing data. The purpose of the data screening is to ensure data is correctly entered or not. The Brainy Insights employs objective and systematic data screening grades involving repeated cycles of quality checks, screening and suspect analysis.
  • Data Integration: Integrating multiple data streams is necessary to produce research studies that provide in-depth picture to the clients. These data streams come from multiple research studies and our in house database. After screening of the data, our analysts conduct creative integration of data sets, optimizing connections between integrated surveys and syndicated data sources. There are mainly 2 research approaches that we follow in order to integrate our data; top down approach and bottom up approach.

Market Deduction & Formulation: The final stage comprises of assigning data points at appropriate market spaces so as to deduce feasible conclusions. Analyst perspective & subject matter expert based holistic form of market sizing coupled with industry analysis also plays a crucial role in this stage.

This stage involves in finalization of the market size and numbers that we have collected from data integration step. With data interpolation, it is made sure that there is no gap in the market data. Successful trend analysis is done by our analysts using extrapolation techniques, which provide the best possible forecasts for the market.

Data Validation & Market Feedback: Validation is the most important step in the process. Validation & re-validation via an intricately designed process helps us finalize data-points to be used for final calculations.

The Brainy Insights interacts with leading companies and experts of the concerned domain to develop the analyst team’s market understanding and expertise. It improves and substantiates every single data presented in the market reports. The data validation interview and discussion panels are typically composed of the most experienced industry members. The participants include, however, are not limited to:

  • CXOs and VPs of leading companies’ specific to sector
  • Purchasing managers, technical personnel, end-users
  • Key opinion leaders such as investment bankers, and industry consultants

Moreover, we always validate our data and findings through primary respondents from all the major regions we are working on.

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