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The global cell-free protein synthesis market is expected to grow from USD 249.02 million in 2022 to USD 487.89 million by 2030, at a CAGR of 8.77% during the forecast period 2022-2030. The North American region is expected to dominate the market in 2022.
Cell-free protein synthesis is a process in which protein is produced using cell-free biological machinery. Cell-free protein synthesis has emerged as a substitute for using living cells in research studies. Cell-free protein synthesis is suitable for proteomics studies and structural biology. It has been proposed as one of the most efficient technologies in bioengineering. The cell-free protein expressions are ideal for interactions between protein and protein and between protein and nucleic acid. The systems used for cell-free protein synthesis are rapid, simple and efficient in synthesizing the required protein. These systems even have the potential to overcome the loopholes present in the current production systems used in applied research. Cell-free protein synthesis can be used to expand the genetic code, produce complex proteins and assemble viruses. Many researchers have found cell-free protein synthesis to emerge as a powerful technology for producing enzymes and membrane proteins.
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In January 2022, a significant player, Thermo Fisher Scientific Inc., acquired another company, PeproTech, for around USD 1.85 billion. This acquisition aimed to integrate PeproTech’s portfolio of recombinant protein with Thermo Fisher’s portfolio of cell culture media.
Drivers:
Increasing cases of chronic and infectious diseases: With rising urbanization and industrialization, the prevalence of chronic and infectious diseases has also increased in many regions. These diseases occur for several reasons, such as unhealthy lifestyle habits, lack of hygiene practices, etc. The spread of highly infectious diseases is majorly through consuming contaminated food particles. Further, contaminants such as bacteria and fungi are responsible for many contagious diseases. The rising population has led to increased population density, further contributing to the spreading of infections from person to person faster. Also, the cases of chronic diseases, infections, etc., have increased drastically in recent years, due to which the emphasis on protein synthesis and development has increased in the current decade. Cell-free protein synthesis has several potential advantages over conventional methods, such as in-vivo technology. The former is way faster and doesn't necessarily require protein purification.
Restraints:
High cost of equipment– The capital expenditure of a cell-free protein synthesis system is high, which acts as a restraint in the market. The medium and small-scale end-user industries find it challenging to cope with the high capital and maintenance costs. The cell-free protein synthesis system offers significant benefits but cannot be afforded by many medium-scale companies.
Opportunities:
Increasing investment in the synthetic genome and biology projects- Pharmaceutical regulations, also known as medicines regulations, is a set of legislative, regulatory, and technological steps taken by governments to ensure the protection, effectiveness, and consistency of medicines, as well as the accuracy and relevance of product details. Pharmaceutical regulations are essential in ensuring licensed medications' safety and effectiveness worldwide. Synthetic biology is a new field of science that tries to make life easier to engineer. Synthetic biology is a rapidly growing branch of science that attempts to make synthetic biology easier for the engineer and widely accessible to rational design. This will help program the biological functions, features, and products in the same way computers can. Engineering biology has potential in critical sectors of the US economy. While the United States now leads in synthetic biology research and development, other countries heavily invest in strengthening their economies. To enhance health status, regulations are expected for both new technologies and existing goods. This has increased demand for cell-free protein synthesis tools owing to the ease of the process.
Challenges:
Lack of standard policies governing the market - Cell-free protein synthesis aims to simulate and maintain cell culture. This endeavour necessitates tight collaboration and communication between the modeller and the experimenter, which standardized workflow formats can aid. However, the present modelling methods do not focus on the building and composition models of complex data. There are no standardized regulations by any government bodies, making it hard for the researchers to adopt a uniform cell-free protein synthesis process across the regions. The researchers working across regions cannot share their biomedical models due to the unavailability of standards for model representation purposes.
Regional segmentation analysis:
The regions analyzed for the market include North America, Europe, South America, Asia Pacific, the Middle East, and Africa. The North American region emerged as the most significant global cell-free protein synthesis market, with a market revenue share of 36.20% in 2022. Given the presence of important market players, the region has a high cell-free protein synthesis market growth rate. The North American market will be driven by the presence of synthetic biology research and development facilities in infrastructure to support the cell-free protein synthesis market, the availability of high-end tools and equipment to support the synthesis process and the increasing incidence of chronic disorders. The growing incidence of various cancers in regional countries has increased the frequency of cell-free protein synthesis. The Asia-Pacific region is anticipated to grow lucratively during the forecast period. The funding for research and development is rising in countries like Japan and China. New technologies are being developed for discovering new drug therapeutics.
North America Region Cell-Free Protein Synthesis Market Share in 2022 - 36.20%
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Method Segment Analysis
The method segment is divided into continuous flow synthesis and batch synthesis. The continuous flow synthesis segment dominated the market with a revenue share of around 65.10% in 2022. Continuous flow synthesis refers to the continuous process of cell-free protein synthesis. The continuous method is more convenient for the researcher than batch synthesis.
Product Segment Analysis
The product segment is divided into lysate systems, accessories and consumables. The lysate system further includes wheat germ, human, insect cells, E. Coli, rabbit reticulocytes and others. The lysate system segment dominated the market with a market share of 62.02% in 2022. Lysate systems are the utmost requirement during cell-free protein synthesis. These are commercially widely available and help in gaining high protein yields. A range of biological therapies requires recombinant technology of lysate systems.
Application Segment Analysis
The application segment includes protein labelling, enzyme engineering, protein purification, and others. The enzyme engineering segment dominated the market with a revenue share of 36.91% in 2022. Enzyme engineering is an emerging field, and cell-free protein synthesis helps briefly understand cell culture. The attributes of protein synthesis include no requirement to maintain cell viability and membrane.
End-user Segment Analysis
The end-user segment includes pharmaceutical and biotechnology companies, academic and research institutes, contract research organizations and others. The pharmaceutical and biotechnology company segment dominated the market with a revenue share of around 44.10% in 2022. Pharmaceutical and biotech companies have a higher demand for cell-free protein synthesis due to the rapid expansion of their manufacturing capabilities. The demand for regenerative medicine has increased drastically. Thus, pharmaceutical and biotech companies invest in cell-free protein synthesis systems.
Report Description:
| Attribute | Description |
|---|---|
| Market Size | Revenue (USD Million) |
| Market size value in 2022 | USD 249.02 Million |
| Market size value in 2030 | USD 487.89 Million |
| CAGR (2022 to 2030) | 8.77% |
| Historical data | 2019-2020 |
| Base Year | 2021 |
| Forecast | 2022-2030 |
| Segments | The research segment is based on method, product, application and end-user. |
| Regional Segments | The regions examined for the market are Europe, Asia Pacific, North America, South America, and Middle East & Africa. |
As per The Brainy Insights, the size of the cell free protein synthesis market was valued 249.02 million in 2022 to USD 487.89 million by 2030.
Global cell free protein synthesis market is growing at a CAGR of 8.77% during the forecast period 2022-2030.
The market's growth will be influenced by the growing prevalence of chronic and infectious diseases.
The high cost of analyzers and instruments used for synthesis could hamper the market growth.
The rising investment in synthetic biology is providing huge opportunities to the market.
1. Introduction
1.1. Objective of the Study
1.2. Market Definition
1.3. Research Scope
1.4. Currency
1.5. Key Target Audience
2. Research Methodology and Assumptions
3. Executive Summary
4. Premium Insights
4.1. Porter’s Five Forces Analysis
4.2. Value Chain Analysis
4.3. Top Investment Pockets
4.3.1. Market Attractiveness Analysis By Method
4.3.2. Market Attractiveness Analysis By Product
4.3.3. Market Attractiveness Analysis By Application
4.3.4. Market Attractiveness Analysis By End-user
4.3.5. Market Attractiveness Analysis By Region
4.4. Industry Trends
5. Market Dynamics
5.1. Market Evaluation
5.2. Drivers
5.2.1. Increasing incidence of chronic and infectious diseases
5.3. Restraints
5.3.1. High capital investment
5.4. Opportunities
5.4.1. Rising investment in synthetic biology
5.5. Challenges
5.5.1. Non-uniform regulations across regions
6. Global Cell Free Protein Synthesis Market Analysis and Forecast, By Method
6.1. Segment Overview
6.2. Continuous Flow Synthesis
6.3. Batch Synthesis
7. Global Cell Free Protein Synthesis Market Analysis and Forecast, By Product
7.1. Segment Overview
7.2. Lysate Systems
7.2.1. Wheat Germ Cell Free Protein Synthesis System
7.2.2. Human Cell Free Protein Synthesis System
7.2.3. Insect Cells Cell Free Protein Synthesis System
7.2.4. E. Coli Cell Free Protein Synthesis System
7.2.5. Rabbit Reticulocytes Cell Free Protein Synthesis System
7.2.6. Others
7.3. Accessories
7.4. Consumables
8. Global Cell Free Protein Synthesis Market Analysis and Forecast, By Application
8.1. Segment Overview
8.2. Protein Labelling
8.3. Enzyme Engineering
8.4. Protein Purification
8.5. Others
9. Global Cell Free Protein Synthesis Market Analysis and Forecast, By End-user
9.1. Segment Overview
9.2. Pharmaceutical and Biotechnology Company
9.3. Academic and Research Institutes
9.4. Contact Research Organizations
9.5. Others
10. Global Cell Free Protein Synthesis Market Analysis and Forecast, By Regional Analysis
10.1. Segment Overview
10.2. North America
10.2.1. U.S.
10.2.2. Canada
10.2.3. Mexico
10.3. Europe
10.3.1. Germany
10.3.2. France
10.3.3. U.K.
10.3.4. Italy
10.3.5. Spain
10.4. Asia-Pacific
10.4.1. Japan
10.4.2. China
10.4.3. India
10.5. South America
10.5.1. Brazil
10.6. Middle East and Africa
10.6.1. UAE
10.6.2. South Africa
11. Global Cell Free Protein Synthesis Market-Competitive Landscape
11.1. Overview
11.2. Market Share of Key Players in the Cell Free Protein Synthesis Market
11.2.1. Global Company Market Share
11.2.2. North America Company Market Share
11.2.3. Europe Company Market Share
11.2.4. APAC Company Market Share
11.3. Competitive Situations and Trends
11.3.1. Product Launches and Developments
11.3.2. Partnerships, Collaborations, and Agreements
11.3.3. Mergers & Acquisitions
11.3.4. Expansions
12. Company Profiles
12.1. Biotech Rabbit
12.1.1. Business Overview
12.1.2. Company Snapshot
12.1.3. Company Market Share Analysis
12.1.4. Company Product Portfolio
12.1.5. Recent Developments
12.1.6. SWOT Analysis
12.2. New England Biolabs
12.2.1. Business Overview
12.2.2. Company Snapshot
12.2.3. Company Market Share Analysis
12.2.4. Company Product Portfolio
12.2.5. Recent Developments
12.2.6. SWOT Analysis
12.3. Genocopies, Inc.
12.3.1. Business Overview
12.3.2. Company Snapshot
12.3.3. Company Market Share Analysis
12.3.4. Company Product Portfolio
12.3.5. Recent Developments
12.3.6. SWOT Analysis
12.4. Promega Corporation
12.4.1. Business Overview
12.4.2. Company Snapshot
12.4.3. Company Market Share Analysis
12.4.4. Company Product Portfolio
12.4.5. Recent Developments
12.4.6. SWOT Analysis
12.5. Merck Kagan
12.5.1. Business Overview
12.5.2. Company Snapshot
12.5.3. Company Market Share Analysis
12.5.4. Company Product Portfolio
12.5.5. Recent Developments
12.5.6. SWOT Analysis
12.6. Jena Biosciences GmbH
12.6.1. Business Overview
12.6.2. Company Snapshot
12.6.3. Company Market Share Analysis
12.6.4. Company Product Portfolio
12.6.5. Recent Developments
12.6.6. SWOT Analysis
12.7. BioCentury Inc.
12.7.1. Business Overview
12.7.2. Company Snapshot
12.7.3. Company Market Share Analysis
12.7.4. Company Product Portfolio
12.7.5. Recent Developments
12.7.6. SWOT Analysis
12.8. Creative Biolabs.
12.8.1. Business Overview
12.8.2. Company Snapshot
12.8.3. Company Market Share Analysis
12.8.4. Company Product Portfolio
12.8.5. Recent Developments
12.8.6. SWOT Analysis
12.9. Bioneer Corporation.
12.9.1. Business Overview
12.9.2. Company Snapshot
12.9.3. Company Market Share Analysis
12.9.4. Company Product Portfolio
12.9.5. Recent Developments
12.9.6. SWOT Analysis
12.10. Sutro Biopharma, Inc.
12.10.1. Business Overview
12.10.2. Company Snapshot
12.10.3. Company Market Share Analysis
12.10.4. Company Product Portfolio
12.10.5. Recent Developments
12.10.6. SWOT Analysis
12.11. Thermo Fisher Scientific, Inc.
12.11.1. Business Overview
12.11.2. Company Snapshot
12.11.3. Company Market Share Analysis
12.11.4. Company Product Portfolio
12.11.5. Recent Developments
12.11.6. SWOT Analysis
12.12. Cube Biotech GmbH
12.12.1. Business Overview
12.12.2. Company Snapshot
12.12.3. Company Market Share Analysis
12.12.4. Company Product Portfolio
12.12.5. Recent Developments
12.12.6. SWOT Analysis
12.13. Takara Bio Company
12.13.1. Business Overview
12.13.2. Company Snapshot
12.13.3. Company Market Share Analysis
12.13.4. Company Product Portfolio
12.13.5. Recent Developments
12.13.6. SWOT Analysis
12.14. CellFree Sciences Co., Ltd.
12.14.1. Business Overview
12.14.2. Company Snapshot
12.14.3. Company Market Share Analysis
12.14.4. Company Product Portfolio
12.14.5. Recent Developments
12.14.6. SWOT Analysis
List of Table
1. Global Cell Free Protein Synthesis Market, By Method, 2019-2030 (USD Million)
2. Global Continuous Flow Synthesis, Cell Free Protein Synthesis Market, By Region, 2019-2030 (USD Million)
3. Global Batch Synthesis, Cell Free Protein Synthesis Market, By Region, 2019-2030 (USD Million)
4. Global Cell Free Protein Synthesis Market, By Product, 2019-2030 (USD Million)
5. Global Lysate Systems, Cell Free Protein Synthesis Market, By Region, 2019-2030 (USD Million)
6. Global Accessories, Cell Free Protein Synthesis Market, By Region, 2019-2030 (USD Million)
7. Global Consumables, Cell Free Protein Synthesis Market, By Region, 2019-2030 (USD Million)
8. Global Cell Free Protein Synthesis Market, By Application, 2019-2030 (USD Million)
9. Global Protein Labelling, Cell Free Protein Synthesis Market, By Region, 2019-2030 (USD Million)
10. Global Enzyme Engineering, Cell Free Protein Synthesis Market, By Region, 2019-2030 (USD Million)
11. Global Protein Purification, Cell Free Protein Synthesis Market, By Region, 2019-2030 (USD Million)
12. Global Others, Cell Free Protein Synthesis Market, By Region, 2019-2030 (USD Million)
13. Global Cell Free Protein Synthesis Market, By End-user, 2019-2030 (USD Million)
14. Global Pharmaceutical and Biotechnology Company, Cell Free Protein Synthesis Market, By Region, 2019-2030 (USD Million)
15. Global Academic and Research Institutes, Cell Free Protein Synthesis Market, By Region, 2019-2030 (USD Million)
16. Global Contact Research Organizations, Cell Free Protein Synthesis Market, By Region, 2019-2030 (USD Million)
17. Global Others, Cell Free Protein Synthesis Market, By Region, 2019-2030 (USD Million)
18. Global Cell Free Protein Synthesis Market, By Region, 2019-2030 (USD Million)
19. North America Cell Free Protein Synthesis Market, By Method, 2019-2030 (USD Million)
20. North America Cell Free Protein Synthesis Market, By Product, 2019-2030 (USD Million)
21. North America Cell Free Protein Synthesis Market, By Application, 2019-2030 (USD Million)
22. North America Cell Free Protein Synthesis Market, By End-user, 2019-2030 (USD Million)
23. U.S. Cell Free Protein Synthesis Market, By Method, 2019-2030 (USD Million)
24. U.S. Cell Free Protein Synthesis Market, By Product, 2019-2030 (USD Million)
25. U.S. Cell Free Protein Synthesis Market, By Application, 2019-2030 (USD Million)
26. U.S. Cell Free Protein Synthesis Market, By End-user, 2019-2030 (USD Million)
27. Canada Cell Free Protein Synthesis Market, By Method, 2019-2030 (USD Million)
28. Canada Cell Free Protein Synthesis Market, By Product, 2019-2030 (USD Million)
29. Canada Cell Free Protein Synthesis Market, By Application, 2019-2030 (USD Million)
30. Canada Cell Free Protein Synthesis Market, By End-user, 2019-2030 (USD Million)
31. Mexico Cell Free Protein Synthesis Market, By Method, 2019-2030 (USD Million)
32. Mexico Cell Free Protein Synthesis Market, By Product, 2019-2030 (USD Million)
33. Mexico Cell Free Protein Synthesis Market, By Application, 2019-2030 (USD Million)
34. Mexico Cell Free Protein Synthesis Market, By End-user, 2019-2030 (USD Million)
35. Europe Cell Free Protein Synthesis Market, By Method, 2019-2030 (USD Million)
36. Europe Cell Free Protein Synthesis Market, By Product, 2019-2030 (USD Million)
37. Europe Cell Free Protein Synthesis Market, By Application, 2019-2030 (USD Million)
38. Europe Cell Free Protein Synthesis Market, By End-user, 2019-2030 (USD Million)
39. Germany Cell Free Protein Synthesis Market, By Method, 2019-2030 (USD Million)
40. Germany Cell Free Protein Synthesis Market, By Product, 2019-2030 (USD Million)
41. Germany Cell Free Protein Synthesis Market, By Application, 2019-2030 (USD Million)
42. Germany Cell Free Protein Synthesis Market, By End-user, 2019-2030 (USD Million)
43. France Cell Free Protein Synthesis Market, By Method, 2019-2030 (USD Million)
44. France Cell Free Protein Synthesis Market, By Product, 2019-2030 (USD Million)
45. France Cell Free Protein Synthesis Market, By Application, 2019-2030 (USD Million)
46. France Cell Free Protein Synthesis Market, By End-user, 2019-2030 (USD Million)
47. U.K. Cell Free Protein Synthesis Market, By Method, 2019-2030 (USD Million)
48. U.K. Cell Free Protein Synthesis Market, By Product, 2019-2030 (USD Million)
49. U.K. Cell Free Protein Synthesis Market, By Application, 2019-2030 (USD Million)
50. U.K. Cell Free Protein Synthesis Market, By End-user, 2019-2030 (USD Million)
51. Italy Cell Free Protein Synthesis Market, By Method, 2019-2030 (USD Million)
52. Italy Cell Free Protein Synthesis Market, By Product, 2019-2030 (USD Million)
53. Italy Cell Free Protein Synthesis Market, By Application, 2019-2030 (USD Million)
54. Italy Cell Free Protein Synthesis Market, By End-user, 2019-2030 (USD Million)
55. Spain Cell Free Protein Synthesis Market, By Method, 2019-2030 (USD Million)
56. Spain Cell Free Protein Synthesis Market, By Product, 2019-2030 (USD Million)
57. Spain Cell Free Protein Synthesis Market, By Application, 2019-2030 (USD Million)
58. Spain Cell Free Protein Synthesis Market, By End-user, 2019-2030 (USD Million)
59. Asia Pacific Cell Free Protein Synthesis Market, By Method, 2019-2030 (USD Million)
60. Asia Pacific Cell Free Protein Synthesis Market, By Product, 2019-2030 (USD Million)
61. Asia Pacific Cell Free Protein Synthesis Market, By Application, 2019-2030 (USD Million)
62. Asia Pacific Cell Free Protein Synthesis Market, By End-user, 2019-2030 (USD Million)
63. Japan Cell Free Protein Synthesis Market, By Method, 2019-2030 (USD Million)
64. Japan Cell Free Protein Synthesis Market, By Product, 2019-2030 (USD Million)
65. Japan Cell Free Protein Synthesis Market, By Application 2019-2030 (USD Million)
66. Japan Cell Free Protein Synthesis Market, By End-user, 2019-2030 (USD Million)
67. China Cell Free Protein Synthesis Market, By Method, 2019-2030 (USD Million)
68. China Cell Free Protein Synthesis Market, By Product, 2019-2030 (USD Million)
69. China Cell Free Protein Synthesis Market, By Application, 2019-2030 (USD Million)
70. China Cell Free Protein Synthesis Market, By End-user, 2019-2030 (USD Million)
71. India Cell Free Protein Synthesis Market, By Method, 2019-2030 (USD Million)
72. India Cell Free Protein Synthesis Market, By Product, 2019-2030 (USD Million)
73. India Cell Free Protein Synthesis Market, By Application, 2019-2030 (USD Million)
74. India Cell Free Protein Synthesis Market, By End-user, 2019-2030 (USD Million)
75. South America Cell Free Protein Synthesis Market, By Method, 2019-2030 (USD Million)
76. South America Cell Free Protein Synthesis Market, By Product, 2019-2030 (USD Million)
77. South America Cell Free Protein Synthesis Market, By Application, 2019-2030 (USD Million)
78. South America Cell Free Protein Synthesis Market, By End-user, 2019-2030 (USD Million)
79. Brazil Cell Free Protein Synthesis Market, By Method, 2019-2030 (USD Million)
80. Brazil Cell Free Protein Synthesis Market, By Product, 2019-2030 (USD Million)
81. Brazil Cell Free Protein Synthesis Market, By Application, 2019-2030 (USD Million)
82. Brazil Cell Free Protein Synthesis Market, By End-user, 2019-2030 (USD Million)
83. Middle East and Africa Cell Free Protein Synthesis Market, By Method, 2019-2030 (USD Million)
84. Middle East and Africa Cell Free Protein Synthesis Market, By Product, 2019-2030 (USD Million)
85. Middle East and Africa Cell Free Protein Synthesis Market, By Application, 2019-2030 (USD Million)
86. Middle East and Africa Cell Free Protein Synthesis Market, By End-user, 2019-2030 (USD Million)
87. UAE Cell Free Protein Synthesis Market, By Method, 2019-2030 (USD Million)
88. UAE Cell Free Protein Synthesis Market, By Product, 2019-2030 (USD Million)
89. UAE Cell Free Protein Synthesis Market, By Application, 2019-2030 (USD Million)
90. UAE Cell Free Protein Synthesis Market, By End-user, 2019-2030 (USD Million)
91. South Africa Cell Free Protein Synthesis Market, By Method, 2019-2030 (USD Million)
92. South Africa Cell Free Protein Synthesis Market, By Product, 2019-2030 (USD Million)
93. South Africa Cell Free Protein Synthesis Market, By Application, 2019-2030 (USD Million)
94. South Africa Cell Free Protein Synthesis Market, By End-user, 2019-2030 (USD Million)
List of Figures
1. Global Cell Free Protein Synthesis Market Segmentation
2. Cell Free Protein Synthesis Market: Research Methodology
3. Market Size Estimation Methodology: Bottom-Up Approach
4. Market Size Estimation Methodology: Top-Down Approach
5. Data Triangulation
6. Porter’s Five Forces Analysis
7. Value Chain Analysis
8. Global Cell Free Protein Synthesis Market Attractiveness Analysis By Method
9. Global Cell Free Protein Synthesis Market Attractiveness Analysis By Product
10. Global Cell Free Protein Synthesis Market Attractiveness Analysis By Application
11. Global Cell Free Protein Synthesis Market Attractiveness Analysis By End-user
12. Global Cell Free Protein Synthesis Market Attractiveness Analysis By Region
13. Global Cell Free Protein Synthesis Market: Dynamics
14. Global Cell Free Protein Synthesis Market Share by Method (2022 & 2030)
15. Global Cell Free Protein Synthesis Market Share by Product (2022 & 2030)
16. Global Cell Free Protein Synthesis Market Share by Application (2022 & 2030)
17. Global Cell Free Protein Synthesis Market Share by End-user (2022 & 2030)
18. Global Cell Free Protein Synthesis Market Share by Regions (2022 & 2030)
19. Global Cell Free Protein Synthesis Market Share by Company (2021)
This study forecasts revenue at global, regional, and country levels from 2019 to 2030. The Brainy Insights has segmented the global cell free protein synthesis market based on below mentioned segments:
Global Cell Free Protein Synthesis Market by Method:
Global Cell Free Protein Synthesis Market by Product:
Global Cell Free Protein Synthesis Market by Application:
Global Cell Free Protein Synthesis Market by End-user:
Global Cell Free Protein Synthesis Market by Region:
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