Alexipharmic Drugs Market

Alexipharmic Drugs Market Size by Application (Alcoholic Overdose, Opioid Overdose, Benzodiazepine Overdose, Benzodiazepine Overdose, and Others), Distribution Channel (Hospital Pharmacies, Retail Pharmacies, Online Pharmacies and Others), Regions, Global Industry Analysis, Share, Growth, Trends, and Forecast 2024 to 2033

Base Year: 2023 Historical Data: 2020-22
  • Report ID: TBI-14072
  • Published Date: Feb, 2024
  • Pages: 237
  • Category: Healthcare
  • Format: PDF
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The global alexipharmic drugs market was valued at USD 3 billion in 2023 and grew at a CAGR of 4% from 2024 to 2033. The market is expected to reach USD 4.44 billion by 2033. The rising cases of opioid overdose will drive the growth of the global alexipharmic drugs market.

Market Introduction:

Alexipharmics or alexipharmic drugs refer to substances counteracting poisons. They are more commonly known as "antidotes." the demand for antidotes is driven by the need to treat specific poisonings or toxic exposures. Antidotes are crucial in emergency medicine and toxicology, where they play a vital role in mitigating the harmful effects of various toxins. The prevalence of specific toxins, accidental poisonings, drug overdoses, and environmental exposures are driving the demand for alexipharmic drugs.

Alexipharmic Drugs Market Size

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Recent Development
  • Rising Pharmaceuticals, a subsidiary of Rising Pharma Holdings Inc., declared the approval, introduction, and instant commercial availability of Edetate calcium disodium injection. This launch will address the significant commercial shortage of this crucial medication in the US.  Rising's edetate calcium disodium injection is recommended for lowering blood lead levels and depot storage in cases of acute and chronic lead poisoning, as well as lead encephalopathy in adults and children.

Market Dynamics:


The increasing instances of poisoning and overdose – The opioid epidemic has led to an increased need for antidotes to counteract opioid overdoses. Accidental or intentional chemical exposures contribute to a demand for antidotes. Instances of poisoning, especially in children, to address accidental ingestions of harmful substances increase the demand for alexipharmic drugs. The increasing awareness of the importance of timely poisoning treatment, driven by public health campaigns and educational initiatives spearheaded by regulatory authorities, contributes to an increased demand for antidotes.


The adverse reactions of alexipharmic drugs adverse reactions including allergic responses such as skin rashes or anaphylaxis, cardiovascular impacts, gastrointestinal symptoms like nausea or vomiting, and neurological effects ranging from dizziness to seizures will limit the market’s growth.  Additionally, antidotes may lead to respiratory distress, haematological complications, or local irritation at injection sites.


Product innovations – Ongoing research in toxicology, supported by advancements in genomic and proteomic technologies, leads to a deeper understanding of toxins and their mechanisms of action, which leads to product innovations. Exploring innovative delivery mechanisms, such as nanotechnology, enhances the speed and precision of antidote deployment, furthering the alexipharmic drugs market. Regulatory requirements prompt pharmaceutical companies to invest in research and development efforts that align with emerging health priorities, fostering innovation. Collaborations among research institutes, industry players and government entities further amplify the market’s growth and development.

  • The death cap mushroom, Amanita phalloides, has long been known as the "killer of kings," yet it may be losing its power. Researchers may have discovered a counteragent for the lethal mushroom's venom.  When scientists discovered a possible remedy lately, they also focused on the human biochemical route required for the toxin from the mushrooms, known as α-amanitin, to enter cells. Indocyanine green, the molecule acting as an antidote, blocks that pathway. The researchers in Nature Communications published these results.
Regional segmentation analysis:

The regions analyzed for the market include North America, Europe, South America, Asia Pacific, the Middle East, and Africa. North America emerged as the most significant global alexipharmic drugs market, with a 35% market revenue share in 2023.

The opioid epidemic, especially in the United States of America, is a significant driver, necessitating the widespread availability of alexipharmic drugs. Environmental hazards, industrial activities, and the potential for chemical exposures in North America amplify the need for alexipharmic drugs to manage and mitigate health risks arising from such incidents. Awareness, education campaigns, and regulatory changes increase demand for alexipharmic drugs. Advancements in pharmaceutical research also contribute to the market’s growth.

North America Region Alexipharmic Drugs Market Share in 2023 - 35%

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  • As the United States struggles to contain the rising number of victims from the fentanyl crisis, a new law will mandate that the Pentagon begin gathering data on overdoses among the ranks in 2024 and provide troops with an antidote for opioid overdoses.  After the yearly defence policy bill was passed last month, the Defence Department will now be required to keep records on substances used in overdoses, whether overdoses also involved doctor-prescribed drugs, and the number of overdoses classified as intentional or accidental.
Application Segment Analysis

The application segment is divided into alcoholic overdose, opioid overdose, benzodiazepine overdose, benzodiazepine overdose, and others. The opioid overdose segment dominated the market, with a market share of around 39% in 2023. The escalating opioid epidemic has led to a critical increase in opioid overdose cases, making alexipharmic drugs crucial in addressing this public health crisis. The overprescribing of opioids, the rise in illicit drug use, polydrug use, the lack of accessible addiction treatment options, the availability of potent opioids like fentanyl, and delayed medical responses in non-medical settings have all contributed to increasing demand for alexipharmic drugs for opioid overdose.

  • A nasal spray drug that is promoted as an additional means of counteracting overdoses brought on by synthetic opioids, such as fentanyl, which kills tens of thousands of Americans annually, was approved by the Food and Drug Administration. Opvee, a spray form of nalmefene, is marketed by drugmaker Indivior as a powerful drug that can prevent overdoses for hours and reverse overdoses rapidly, potentially saving lives. Opvee enters the expanding market for drugs that reverse overdose at a pivotal point in the country's drug issue.
Distribution Channel Segment Analysis

The distribution channel segment is divided into hospital pharmacies, retail pharmacies, online pharmacies and others. The hospital pharmacies segment dominated, with a market share of around 42% in 2023. hospital pharmacists ensure the safe and effective dispensing of antidotes, given their staff's expertise. Hospital pharmacies adhere to strict storage and handling guidelines, ensuring the stability and reliability of antidotes during emergencies, which fosters trust in consumers. Hospital pharmacies are preferred for purchasing antidotes due to their expertise, regulatory adherence, collaborative approach to patient care, and commitment to ensuring the availability of critical medications in emergencies within the hospital setting.

  • Retail stores and internet retailers will carry the first over-the-counter naloxone—a medication used to counteract opiate overdose—in stock.  The medication's manufacturer, Emergent BioSolutions, stated in a news release that the suggested retail price for the Narcan brand is $44.99 for a carton containing two doses. Initially, Walgreens, Rite Aid, Walmart, and CVS are among the shops that will sell it in-person and online. In March, the US Food and Drug Administration authorized Narcan for over-the-counter use in response to a record number of deaths from opioid overdoses, which are primarily caused by potent synthetic narcotics like fentanyl. Naloxone can be overdosed and revived in minutes with Narcan, a nasal spray version of the drug.
Some of the Key Market Players:
  • Alkermes, Inc.
  • B. Braun Melsungen AG
  • Bausch Health Companies Inc.
  • Emergent BioSolutions
  • Ethypharm S. A.
  • Fresenius SE & Co. KGaA
  • Hikma Pharmaceuticals
  • Merck & Co., Inc.
  • Mylan N.V.
  • SGPharma Pvt. Ltd.

Report Description:

Attribute Description
Market Size Revenue (USD Billion)
Market size value in 2023 USD 3 Billion
Market size value in 2033 USD 4.44 Billion
CAGR (2024 to 2033) 4%
Historical data 2020-2022
Base Year 2023
Forecast 2024-2033
Region The regions analyzed for the market are Asia Pacific, Europe, South America, North America, and Middle East and Africa. Furthermore, the regions are further analyzed at the country level.
Segments Application and Distribution Channel

Frequesntly Asked Questions

As per The Brainy Insights, the size of the global alexipharmic drugs market was valued at USD 3 billion in 2023 to USD 4.44 billion by 2033.

Global alexipharmic drugs market is growing at a CAGR of 4% during the forecast period 2024-2033.

The market's growth will be influenced by the increasing instances of poisoning and overdose.

The adverse reactions of alexipharmic drugs could hamper the market growth.

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This study forecasts revenue at global, regional, and country levels from 2020 to 2033. The Brainy Insights has segmented the global alexipharmic drugs market based on below mentioned segments:

Global Alexipharmic Drugs Market by Application:

  • Alcoholic Overdose
  • Opioid Overdose
  • Benzodiazepine Overdose
  • Benzodiazepine Overdose
  • Others

Global Alexipharmic Drugs Market by Distribution Channel:

  • Hospital Pharmacies
  • Retail Pharmacies
  • Online Pharmacies
  • Others

Global Alexipharmic Drugs Market by Region:

  • North America
    • U.S.
    • Canada
    • Mexico
  • Europe
    • Germany
    • France
    • U.K.
    • Italy
    • Spain
  • Asia-Pacific
    • Japan
    • China
    • India
  • South America
    • Brazil
  • Middle East and Africa  
    • UAE
    • South Africa


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